Document Detail

Signaling to translational control pathways: diversity in gene regulation in inflammatory and vascular cells.
MedLine Citation:
PMID:  15795158     Owner:  NLM     Status:  MEDLINE    
The expression of a subset of genes is strongly controlled at translational checkpoints, a major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive outside-in signals to specialized pathways that regulate translation of specific messenger RNAs in a transcript-specific fashion and thereby influence key features of cellular phenotype. These pathways and the expression of proteins that they control may be dysregulated in cardiovascular diseases and are therapeutic targets.
Stephan W Lindemann; Andrew S Weyrich; Guy A Zimmerman
Related Documents :
9641918 - Drosophila synapse formation: regulation by transmembrane protein with leu-rich repeats...
25400128 - Rna-guided transcriptional regulation in planta via synthetic dcas9-based transcription...
20652998 - Developmental timing of mrna translation--integration of distinct regulatory elements.
25460578 - Isolation and gene expression of haematopoietic-cell-free preparations of highly purifi...
19196098 - Analysis of putative mirna binding sites and mrna 3' ends as targets for sirna-mediated...
18543298 - The irg mouse: a two-color fluorescent reporter for assessing cre-mediated recombinatio...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  15     ISSN:  1050-1738     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-03-29     Completed Date:  2005-08-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9-17     Citation Subset:  IM    
Department of Internal Medicine and the Program in Human Molecular Biology and Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiovascular Diseases / genetics*,  physiopathology
Gene Expression Regulation*
Inflammation / genetics*,  physiopathology
Neutrophils / metabolism*
Protein Biosynthesis / genetics*
RNA, Messenger / genetics*
Signal Transduction*
Grant Support
Reg. No./Substance:
0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Role of progenitor cells in transplant arteriosclerosis.
Next Document:  Imaging of atherosclerosis -- can we predict plaque rupture?