| Signaling pathways in T follicular helper cells. | |
| | |
MedLine Citation:
|
PMID: 20525897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Th cell functional subsets have unique transcriptional programs that form the molecular basis for T cell differentiation and functions. T follicular helper (TFH) cells have emerged as the main providers of T cell help to B cells during the germinal center (GC) reaction, where B cells undergo selection events through competition for Ag and for access to GC T cell-mediated prosurvival and differentiation signals. Because T cell help is one limiting factor for GC B cells, the molecular mechanisms controlling TFH cell abundance and functionality are central to the GC reaction and generation of long-term humoral immunity. Two signaling pathways are absolutely critical for TFH cells: phosphoinositide-3 kinase pathway and the signaling lymphocyte activation molecule-associated protein. In this review, the molecular mechanisms constituting the signaling network in TFH cells will be explored. |
| | |
Authors:
|
Julia Rolf; Kirsten Fairfax; Martin Turner |
Related Documents
:
|
19733047 - Engineering multicellular systems by cell-cell communication. 12530957 - Bringing classical embryology to c elegans gastrulation. 19846667 - Distinct roles for carmil isoforms in cell migration. 19869637 - Cell proliferation response to sulfhydryl in mammals. 23312577 - Thy-1 knockdown retards wound repair in mouse skin. 12444547 - Myod induces apoptosis in the absence of rb function through a p21(waf1)-dependent re-l... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 184 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-07 Completed Date: 2010-06-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 6563-8 Citation Subset: AIM; IM |
Affiliation:
|
Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Germinal Center / immunology* Humans Lymphocyte Activation / immunology Signal Transduction / immunology* T-Lymphocyte Subsets / immunology* T-Lymphocytes, Helper-Inducer / immunology* |
| Grant Support | |
ID/Acronym/Agency:
|
//Biotechnology and Biological Sciences Research Council; //Medical Research Council |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Naturally Activated V{gamma}4 {gamma}{delta} T Cells Play a Protective Role in Tumor Immunity throug...
Next Document: Inhibition of PI3k class III-dependent autophagy prevents apoptosis and necrosis by oxidative stress...