| Signaling pathways of PAX2 and its role in renal interstitial fibrosis and glomerulosclerosis. | |
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MedLine Citation:
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PMID: 23137159 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PAX2, a nuclear transcription factor in renal development, is strongly expressed during kidney development and plays an important role in kidney development, differentiation, and renal cell proliferation. PAX2 is expressed in epithelial cells of fetal kidneys and its expression is up-regulated in certain pathologic conditions. However, the transcription activation of PAX2 and its signaling pathways are complicated. Recent discoveries find that the PAX2 gene is pivotal in kidney development and it is implicated in the pathogenesis of renal interstitial fibrosis (RIF) and glomerulosclerosis (GS). Here, I comprehensively reviewed the signal transduction pathways of PAX2 and its role in the pathogenesis of RIF and GS. |
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Authors:
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Tian-Biao Zhou |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-9 |
Journal Detail:
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Title: Journal of receptor and signal transduction research Volume: - ISSN: 1532-4281 ISO Abbreviation: J. Recept. Signal Transduct. Res. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9509432 Medline TA: J Recept Signal Transduct Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pediatric Nephrology, The First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi , China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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