Document Detail


Signaling pathways of PAX2 and its role in renal interstitial fibrosis and glomerulosclerosis.
MedLine Citation:
PMID:  23137159     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PAX2, a nuclear transcription factor in renal development, is strongly expressed during kidney development and plays an important role in kidney development, differentiation, and renal cell proliferation. PAX2 is expressed in epithelial cells of fetal kidneys and its expression is up-regulated in certain pathologic conditions. However, the transcription activation of PAX2 and its signaling pathways are complicated. Recent discoveries find that the PAX2 gene is pivotal in kidney development and it is implicated in the pathogenesis of renal interstitial fibrosis (RIF) and glomerulosclerosis (GS). Here, I comprehensively reviewed the signal transduction pathways of PAX2 and its role in the pathogenesis of RIF and GS.
Authors:
Tian-Biao Zhou
Related Documents :
9454939 - Subclinical cyathostomiasis and unidentified helminthiasis in a juvenile emu (dromaius ...
7086069 - Renal and cutaneous vasomotor and respiratory rate adjustments to peripheral cold and w...
15233199 - Osteopetrorickets.
8958319 - Type 3 pfeiffer syndrome with normal thumbs.
20534279 - Prevalence and clinical impact of polyomaviruses ki and wu in lung transplant recipients.
2572719 - Type 1 fimbriate strains of escherichia coli initiate renal parenchymal scarring.
7529399 - Endothelium derived relaxing factor is involved in the pressure control of renin gene e...
9454939 - Subclinical cyathostomiasis and unidentified helminthiasis in a juvenile emu (dromaius ...
7217389 - Cytophagic histiocytic panniculitis with fever, cytopenia, liver failure, and terminal ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  Journal of receptor and signal transduction research     Volume:  -     ISSN:  1532-4281     ISO Abbreviation:  J. Recept. Signal Transduct. Res.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9509432     Medline TA:  J Recept Signal Transduct Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pediatric Nephrology, The First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi , China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Individual NSAIDs and upper gastrointestinal complications: a systematic review and meta-analysis of...
Next Document:  Safety and Efficacy of Subcutaneous Hepatitis B Immunoglobulin After Liver Transplantation: An Open ...