Document Detail


Signaling pathway of glutamate in the vestibular nuclei following acute hypotension in rats.
MedLine Citation:
PMID:  18639534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute hypotension induces excitation of electrical activity and expression of c-Fos protein and phosphorylated extracellular signal-regulated kinase (pERK) in the vestibular nuclei. Expression of c-Fos protein and pERK is mediated by the excitatory neurotransmitter, glutamate. In this study, in order to investigate the signaling pathway of glutamate in the vestibular nuclei following acute hypotension, expression of the NR2B subunit of glutamate N-methyl-D-aspartate (NMDA) receptors and the GluR1 subunit of glutamate alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors was measured by Western blotting in the medial vestibular nucleus (MVN) following acute hypotension in bilateral labyrinthectomized (BL) rats. In intact labyrinthine animals, acute hypotension increased expression of pGluR1 and pNR2B in the MVN. Expression of pGluR1 Ser831 and Ser845 peaked at 5 and 30 min after acute hypotension and expression of pNR2B peaked at 60 min after acute hypotension, respectively. In BL animals, expression of pGluR1 Ser831, pGluR1 Ser845, and pNR2B was decreased significantly compared to intact labyrinthine animals following acute hypotension. These results suggest that excitatory afferent signals from the peripheral vestibular receptors, resulting from acute hypotension, release glutamate into postsynaptic neurons in the vestibular nuclei and the excitatory signals are transmitted through the GluR1 subunit of the AMPA receptors and the NR2B subunits of the NMDA receptors in the vestibular system.
Authors:
Myoung Ae Choi; Jae Hee Lee; Ji Hyo Hwang; Suck Jun Choi; Min Sun Kim; Byung Rim Park
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-02
Journal Detail:
Title:  Brain research     Volume:  1229     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-26     Completed Date:  2009-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  111-7     Citation Subset:  IM    
Affiliation:
Department of Physiology, Wonkwang University College of Medicine, and VestibuloCochlear Research Center at Wonkwang University, Iksan 570-749, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arsanilic Acid / pharmacology
Gene Expression Regulation / physiology
Glutamic Acid / metabolism*
Hypotension / etiology,  pathology*
Male
Rats
Rats, Sprague-Dawley
Receptors, AMPA / metabolism
Receptors, N-Methyl-D-Aspartate / metabolism
Serine / metabolism
Signal Transduction / drug effects,  physiology*
Time Factors
Vestibular Nuclei / drug effects,  metabolism*
Vestibule, Labyrinth / surgery
Chemical
Reg. No./Substance:
0/Arsanilic Acid; 0/NR2B NMDA receptor; 0/Receptors, AMPA; 0/Receptors, N-Methyl-D-Aspartate; 0/glutamate receptor ionotropic, AMPA 1; 56-45-1/Serine; 56-86-0/Glutamic Acid

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