Document Detail


Signaling organelles of the innate immune system.
MedLine Citation:
PMID:  23217704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are at least five families of microbe-detection receptors that function to detect and eradicate potentially infectious microorganisms that enter multicellular eukaryotes. While a multitude of proteins regulating innate immune signal transduction have already been defined, continuous genetic screening for regulators of innate immunity may not yield as significant insight into the operation of these pathways as was obtained in the past. This diminished return on experimental investment suggests that we are approaching the asymptote of genetics-only approaches to study innate immunity. In contrast, it remains unclear how known regulators of innate immunity interact within the infrastructure of mammalian cells to execute their signaling functions. In this Perspective, I first highlight the locations within mammalian cells that permit innate immune signal transduction and then offer a model whereby structurally distinct proteins can be grouped functionally through their ability to assemble platforms of regulators on the signaling organelles of the innate immune system.
Authors:
Jonathan C Kagan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell     Volume:  151     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-02-06     Revised Date:  2013-12-12    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1168-78     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Immunity, Innate*
Organelles / metabolism*
Receptors, Cytokine / metabolism
Receptors, Pattern Recognition / metabolism
Signal Transduction*
Toll-Like Receptors / metabolism
Grant Support
ID/Acronym/Agency:
AI072955/AI/NIAID NIH HHS; AI093589/AI/NIAID NIH HHS; R00 AI072955/AI/NIAID NIH HHS; R01 AI093589/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Cytokine; 0/Receptors, Pattern Recognition; 0/Toll-Like Receptors
Comments/Corrections

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