| Signaling molecules involved in lipid-induced pancreatic beta-cell dysfunction. | |
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MedLine Citation:
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PMID: 23347443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The increasing incidence of type 2 diabetes mellitus is partially due to the rising obesity rates and the elevated levels of free fatty acids (FFAs). It is known that FFAs are putative mediators of beta-cell dysfunction, which is characterized with impaired glucose-stimulated insulin secretion and increased apoptosis, being defined as lipotoxicity. To date, many factors and their related signal pathways have been reported to be involved in FFA-induced beta-cell dysfunction. However, the entire blueprint is still not obtained. Some essential and newfound effectors, including the sterol regulatory element-binding protein (SREBP)-1c, farnesoid X receptor (FXR), forkhead box-containing protein O (FoxO) 1, ubiquitin C-terminal hydrolase L (UCHL) 1, N-myc downstream-regulated gene (NDRG) 2, perilipin family proteins, silent information regulator 2 protein 1 (Sirt1), pituitary adenylate cyclase-activating polypeptide (PACAP), and ghrelin are described in this review, which may help to further understand the molecular network for lipotoxicity. |
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Authors:
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Shiying Shao; Yan Yang; Gang Yuan; Muxun Zhang; Xuefeng Yu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: DNA and cell biology Volume: 32 ISSN: 1557-7430 ISO Abbreviation: DNA Cell Biol. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-25 Completed Date: 2013-03-21 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9004522 Medline TA: DNA Cell Biol Country: United States |
Other Details:
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Languages: eng Pagination: 41-9 Citation Subset: IM |
Affiliation:
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Division of Endocrinology, Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, People's Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Mellitus, Type 2 / chemically induced*, genetics*, metabolism, physiopathology Forkhead Transcription Factors / genetics, metabolism, physiology Humans Insulin-Secreting Cells / drug effects, metabolism*, physiology Lipids / adverse effects*, pharmacology Models, Biological Receptors, Cytoplasmic and Nuclear / genetics, metabolism, physiology Signal Transduction / drug effects, genetics*, physiology Sterol Regulatory Element Binding Protein 1 / genetics, metabolism, physiology |
| Chemical | |
Reg. No./Substance:
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0/FOXO1 protein, human; 0/Forkhead Transcription Factors; 0/Lipids; 0/Receptors, Cytoplasmic and Nuclear; 0/Sterol Regulatory Element Binding Protein 1; 0/farnesoid X-activated receptor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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