Document Detail


Signaling molecules involved in lipid-induced pancreatic beta-cell dysfunction.
MedLine Citation:
PMID:  23347443     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The increasing incidence of type 2 diabetes mellitus is partially due to the rising obesity rates and the elevated levels of free fatty acids (FFAs). It is known that FFAs are putative mediators of beta-cell dysfunction, which is characterized with impaired glucose-stimulated insulin secretion and increased apoptosis, being defined as lipotoxicity. To date, many factors and their related signal pathways have been reported to be involved in FFA-induced beta-cell dysfunction. However, the entire blueprint is still not obtained. Some essential and newfound effectors, including the sterol regulatory element-binding protein (SREBP)-1c, farnesoid X receptor (FXR), forkhead box-containing protein O (FoxO) 1, ubiquitin C-terminal hydrolase L (UCHL) 1, N-myc downstream-regulated gene (NDRG) 2, perilipin family proteins, silent information regulator 2 protein 1 (Sirt1), pituitary adenylate cyclase-activating polypeptide (PACAP), and ghrelin are described in this review, which may help to further understand the molecular network for lipotoxicity.
Authors:
Shiying Shao; Yan Yang; Gang Yuan; Muxun Zhang; Xuefeng Yu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  DNA and cell biology     Volume:  32     ISSN:  1557-7430     ISO Abbreviation:  DNA Cell Biol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-25     Completed Date:  2013-03-21     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9004522     Medline TA:  DNA Cell Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus, Type 2 / chemically induced*,  genetics*,  metabolism,  physiopathology
Forkhead Transcription Factors / genetics,  metabolism,  physiology
Humans
Insulin-Secreting Cells / drug effects,  metabolism*,  physiology
Lipids / adverse effects*,  pharmacology
Models, Biological
Receptors, Cytoplasmic and Nuclear / genetics,  metabolism,  physiology
Signal Transduction / drug effects,  genetics*,  physiology
Sterol Regulatory Element Binding Protein 1 / genetics,  metabolism,  physiology
Chemical
Reg. No./Substance:
0/FOXO1 protein, human; 0/Forkhead Transcription Factors; 0/Lipids; 0/Receptors, Cytoplasmic and Nuclear; 0/Sterol Regulatory Element Binding Protein 1; 0/farnesoid X-activated receptor
Comments/Corrections

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