| Signaling meets chromatin during tissue regeneration in Drosophila. | |
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MedLine Citation:
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PMID: 16919444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As transcription programs become stabilized in fate-determined cells by progressive patterning of chromatin structures, cells lose their plasticity and the ability to freely modify their identity in response to changing developmental cues. By contrast, stem cells maintain this flexibility, enabling them to embark on different determination pathways. However, regeneration of tissue requires an exception because determined cells are forced to switch their transcription programs to reconstruct the missing tissue. In Drosophila, proliferating cells in the regenerating imaginal discs can even switch to a new disc identity. New studies show that the increased plasticity observed during regeneration results from the action of multiple signaling pathways on chromatin malleability, cell-cycle profiles, and expression of 'stemness' genes. Understanding how signaling pathways can integrate to switch determined cells into multipotent cells has a great medical potential, especially in the field of tissue engineering and remodeling. |
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Authors:
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Cédric Maurange; Nara Lee; Renato Paro |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-08-17 |
Journal Detail:
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Title: Current opinion in genetics & development Volume: 16 ISSN: 0959-437X ISO Abbreviation: Curr. Opin. Genet. Dev. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-18 Completed Date: 2006-11-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111375 Medline TA: Curr Opin Genet Dev Country: England |
Other Details:
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Languages: eng Pagination: 485-9 Citation Subset: IM |
Affiliation:
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MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatin / genetics* Drosophila / genetics*, metabolism* Gene Expression Regulation Regeneration / genetics*, physiology* Signal Transduction* Stem Cells / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Chromatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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