| Signaling mechanisms utilized by antigen receptors and integrins: common intermediates, different outcomes? | |
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MedLine Citation:
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PMID: 17127307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antigen receptors and integrins are structurally and functionally distinct, but both play key roles in regulating immune cell activation and function. Understanding the molecular basis of the signaling pathways utilized by antigen receptors and integrins is fundamental to identifying the mechanisms underlying immune system function and dysfunction (e.g. autoimmune disease) and identifying potential targets for modifying the immune response with therapy. Recently, several key regulators of antigen receptor signaling have also been revealed to be important molecular intermediates in integrin-triggered signaling pathways. These include the protein tyrosine kinase Syk, the guanine nucleotide exchange factor Vav, and the adaptor protein SLP-76. While antigen-receptor signaling is generally associated with leukocyte activation and differentiation, integrins are most commonly thought of as adhesive receptors. This raises the interesting question of how common molecular intermediates may regulate diverse cellular processes such as activation versus adhesion and migration, and provides a framework for defining potentially unique mechanisms utilized by cells of the immune system to regulate integrin-dependent cell function. |
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Authors:
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Nancy Luckashenak; James Lindsey Clements |
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Publication Detail:
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Type: Journal Article; Review Date: 2007-01-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 12 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2007 |
Date Detail:
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Created Date: 2006-11-27 Completed Date: 2007-08-23 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 419-36 Citation Subset: IM |
Affiliation:
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Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo NY 14263, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing
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metabolism Animals Humans Integrins / metabolism* Intracellular Signaling Peptides and Proteins / metabolism Lymphocyte Activation Protein-Tyrosine Kinases / metabolism Receptors, Antigen, T-Cell / metabolism* Signal Transduction* T-Lymphocytes / enzymology, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/Integrins; 0/Intracellular Signaling Peptides and Proteins; 0/Receptors, Antigen, T-Cell; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.1/Syk kinase |
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