| Signaling at neuro/immune synapses. | |
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MedLine Citation:
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PMID: 22466656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunological and neural synapses share properties such as the synaptic cleft, adhesion molecules, stability, and polarity. However, the mismatch in scale has limited the utility of these comparisons. The discovery of phosphatase micro-exclusion from signaling elements in immunological synapses and innate phagocytic synapses define a common functional unit at a common sub-micron scale across synapse types. Bundling of information from multiple antigen receptor microclusters by an immunological synapse has parallels to bundling of multiple synaptic inputs into a single axonal output by neurons, allowing integration and coincidence detection. Bonafide neuroimmune synapses control the inflammatory reflex. A better understanding of the shared mechanisms between immunological and neural synapses could aid in the development of new therapeutic modalities for immunological, neurological, and neuroimmunological disorders alike. |
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Authors:
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Michael L Dustin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2012-04-02 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 122 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-02 Completed Date: 2012-07-06 Revised Date: 2013-02-20 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 1149-55 Citation Subset: AIM; IM |
Affiliation:
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The Helen L. and Martin S. Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA. michael.dustin@med.nyu.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD45 / physiology Biological Evolution Dendritic Cells / immunology Humans Immunologic Capping Immunological Synapses / physiology* Inflammation / immunology, physiopathology Lymphocyte Cooperation Models, Biological Models, Immunological Neuroimmunomodulation / physiology Neurons / physiology Phagocytosis Phosphorylation Protein Processing, Post-Translational Receptors, Immunologic / immunology Signal Transduction / physiology Synapses / physiology* Vagus Nerve / physiology |
| Grant Support | |
ID/Acronym/Agency:
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PN2EY016586/EY/NEI NIH HHS; R37AI543542/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Immunologic; EC 3.1.3.48/Antigens, CD45 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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