Document Detail

Signaling Pathways that Control Cell Proliferation.
MedLine Citation:
PMID:  23457258     Owner:  NLM     Status:  In-Data-Review    
Cells decide to proliferate or remain quiescent using signaling pathways that link information about the cellular environment to the G phase of the cell cycle. Progression through G phase is controlled by pRB proteins, which function to repress the activity of E2F transcription factors in cells exiting mitosis and in quiescent cells. Phosphorylation of pRB proteins by the G cyclin-dependent kinases (CDKs) releases E2F factors, promoting the transition to S phase. CDK activity is primarily regulated by the binding of CDK catalytic subunits to cyclin partners and CDK inhibitors. Consequently, both mitogenic and antiproliferative signals exert their effects on cell proliferation through the transcriptional regulation and ubiquitin-dependent degradation of cyclins and CDK inhibitors.
Robert J Duronio; Yue Xiong
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Publication Detail:
Type:  Journal Article     Date:  2013-03-01
Journal Detail:
Title:  Cold Spring Harbor perspectives in biology     Volume:  5     ISSN:  1943-0264     ISO Abbreviation:  Cold Spring Harb Perspect Biol     Publication Date:  2013  
Date Detail:
Created Date:  2013-03-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101513680     Medline TA:  Cold Spring Harb Perspect Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Department of Biology and Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
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