Document Detail

Signaling pathways in cell polarity.
MedLine Citation:
PMID:  22553378     Owner:  NLM     Status:  MEDLINE    
A key function of signal transduction during cell polarization is the creation of spatially segregated regions of the cell cortex that possess different lipid and protein compositions and have distinct functions. Polarity can be initiated spontaneously or in response to signaling inputs from adjacent cells or soluble factors and is stabilized by positive-feedback loops. A conserved group of proteins, the Par proteins, plays a central role in polarity establishment and maintenance in many contexts. These proteins generate and maintain their distinct locations in cells by actively excluding one another from specific regions of the plasma membrane. The Par signaling pathway intersects with multiple other pathways that control cell growth, death, and organization.
Luke Martin McCaffrey; Ian G Macara
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Publication Detail:
Type:  Journal Article     Date:  2012-06-01
Journal Detail:
Title:  Cold Spring Harbor perspectives in biology     Volume:  4     ISSN:  1943-0264     ISO Abbreviation:  Cold Spring Harb Perspect Biol     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-04     Completed Date:  2012-10-11     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  101513680     Medline TA:  Cold Spring Harb Perspect Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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MeSH Terms
Cell Polarity*
Membrane Proteins / metabolism
Protein Biosynthesis
RNA, Messenger / genetics
Signal Transduction*
Reg. No./Substance:
0/Membrane Proteins; 0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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