| Signaling of Cytokines is Important in Regulation of GnRH Neurons. | |
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MedLine Citation:
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PMID: 22161498 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cytokines encompass a broad class of peptides that mediate signals in a broad range of physiological situations including inflammation, infection, and obesity. The cytokine receptor-associated tyrosine kinase, Jak2, is one of the most important proteins mediating cytokine signaling pathway activation. Recently, our group has demonstrated that Jak2 signaling in the gonadotropin-releasing hormone (GnRH) neuron plays a critical role in fertility in males and females, implicating cytokine activation of the neuron in GnRH neuronal development and function. To date, the specific cytokine(s) essential for activating Jak2 during neuroendocrine development are not known. In this article, we review the evidence for the role of several class 1 cytokines in regulating GnRH neuronal development, GnRH secretion, and GnRH expression. |
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Authors:
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Sheng Wu; Andrew Wolfe |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-13 |
Journal Detail:
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Title: Molecular neurobiology Volume: - ISSN: 1559-1182 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8900963 Medline TA: Mol Neurobiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA, swu24@jhmi.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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