| Insulin/Insulin-like growth factor signaling controls non-Dauer developmental speed in the nematode Caenorhabditis elegans. | |
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MedLine Citation:
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PMID: 20944013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Identified as a major pathway controlling entry in the facultative dauer diapause stage, the DAF-2/Insulin receptor (InsR) signaling acts in multiple developmental and physiological regulation events in Caenorhabditis elegans. Here we identified a role of the insulin-like pathway in controlling developmental speed during the C. elegans second larval stage. This role relies on the canonical DAF-16/FOXO-dependent branch of the insulin-like signaling and is largely independent of dauer formation. Our studies provide further evidence for broad conservation of insulin/insulin-like growth factor (IGF) functions in developmental speed control. |
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Authors:
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Anne-Françoise Ruaud; Iskra Katic; Jean-Louis Bessereau |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-13 |
Journal Detail:
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Title: Genetics Volume: 187 ISSN: 1943-2631 ISO Abbreviation: Genetics Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-12 Completed Date: 2011-04-20 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0374636 Medline TA: Genetics Country: United States |
Other Details:
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Languages: eng Pagination: 337-43 Citation Subset: IM |
Affiliation:
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Ecole Normale Supérieure, Biology of the Ecole Normale Supérieure, F-75005 Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Animals Caenorhabditis elegans / cytology*, drug effects, growth & development*, metabolism Caenorhabditis elegans Proteins / genetics, metabolism* Dimethylphenylpiperazinium Iodide / pharmacology Insulin / metabolism* Larva / drug effects, growth & development, metabolism Receptor, Insulin / genetics, metabolism Signal Transduction* / drug effects Somatomedins / metabolism* Time Factors Transcription Factors / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Caenorhabditis elegans Proteins; 0/DAF-2 protein, C elegans; 0/Somatomedins; 0/Transcription Factors; 0/daf-16 protein, C elegans; 11061-68-0/Insulin; 54-77-3/Dimethylphenylpiperazinium Iodide; EC 2.7.10.1/Receptor, Insulin |
| Comments/Corrections | |
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