Document Detail


Signal transduction pathways participating in homeostasis and malignant transformation of the intestinal tissue.
MedLine Citation:
PMID:  22862172     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Intestinal homeostasis is a complex and tightly regulated process governed by a variety of signalling pathways that balance cell proliferation and differentiation. As revealed by extensive use of defined mouse models, perturbations within the signalling circuitry trigger initial expansion of premalignant cells. In this review, we attempt to summarise recent advances in the knowledge of the cellular signalling mechanisms that drive tumorigenesis in the human and mouse intestine. Keywords: colorectal cancer, epithelium, gut, intestine, mouse models, stem cells.
Authors:
M Krausova; V Korinek
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-05
Journal Detail:
Title:  Neoplasma     Volume:  -     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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