| Signal transduction in the aging immune system. | |
| | |
MedLine Citation:
|
PMID: 16061371 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
T cells from aged mice show defects in the early stages of the activation process, including alterations in cytoskeletal reorganization that precede discrimination, by the T cell receptor, of agonist from antagonist peptides. Aging also modifies the pattern of glycosylation of T cell surface macromolecules, and enzymatic cleavage of these modified glycoproteins can restore high level responses to T cells from aged mice. Alterations in plasma membrane lipids and cholesterol-rich microdomains might also contribute to age-related deficits in T cell signaling. Evidence for intrinsic signal defects in aged B cells is more limited, but might involve pathways that activate the transcription factor E47, which has been implicated in somatic hypermutation and class-switch recombination. |
| | |
Authors:
|
Amir A Sadighi Akha; Richard A Miller |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Current opinion in immunology Volume: 17 ISSN: 0952-7915 ISO Abbreviation: Curr. Opin. Immunol. Publication Date: 2005 Oct |
Date Detail:
|
Created Date: 2005-08-30 Completed Date: 2005-10-27 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8900118 Medline TA: Curr Opin Immunol Country: England |
Other Details:
|
Languages: eng Pagination: 486-91 Citation Subset: IM |
Affiliation:
|
Department of Veterans Affairs Medical Center, Ann Arbor, Michigan 48109-0940, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging* Animals B-Lymphocytes / immunology Humans Models, Immunological* Signal Transduction / immunology* T-Lymphocytes / immunology* |
| Grant Support | |
ID/Acronym/Agency:
|
AG08808/AG/NIA NIH HHS; AG19619/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fibronectin fibrillogenesis, a cell-mediated matrix assembly process.
Next Document: The finasteride prostate cancer prevention trial (PCPT)--what have we learned?