Document Detail

Signal transducer and activator of transcription and the risk of rheumatoid arthritis and thyroid autoimmune disorders.
MedLine Citation:
PMID:  21418779     Owner:  NLM     Status:  Publisher    
OBJECTIVES: The signal transducer and activator of transcription 4 (STAT4) gene localised on chromosome 2q32.2-q32.3 is known to be essential for mediating responses to interleukin 12 in lymphocytes and regulating the differentiation of T helper cells. The aim of this study was to investigate the role of the STAT4 gene in susceptibility to rheumatoid arthritis (RA) and autoimmune thyroid diseases (AITDs) in Tunisian case control studies. METHODS: Genotyping of STAT4 rs7574865 single nucleotide polymorphism (SNP) was performed in 140 patients affected with RA, 159 patients affected with AITDs and 200 healthy controls using TaqMan® allelic discrimination assay. Data were analysed by χ2-test, genotype relative risk (GRR) and odds ratio (OR). RESULTS: Our results revealed that frequencies of the T allele and the T/T genotype were significantly higher among RA patients compared to controls (p=0.008; p=0.003, respectively). However, no significant associations with the risk of autoimmune thyroid diseases were detected. Moreover, the stratification of RA patients subgroups revealed a significant association of both T allele and T/T genotype in patients presented erosion (p=0.003; p=0.004, respectively) as well as anti-cyclic peptides-negative RA (ACPA-) (p=0.002; p=0.0003, respectively). Furthermore, genotypic association was found according to the absence of rheumatoid factor antibody (RF) (p=0.0014). But, no significant differences in allele and genotype frequencies of STAT4 rs7574865 polymorphism were detected according to the presence of another autoimmune disease, nodules and in HLA-DRB1*04 and HLA-DRB1*0404 positive subgroups. CONCLUSIONS: Our results support involvement of the STAT4 gene in the genetic susceptibility to RA but not to AITDs in the Tunisian population.
Mariem Ben Hamad; Francois Cornelis; Hamdi Mbarek; Ghazi Chabchoub; Sameh Marzouk; Zouhir Bahloul; Ahmed Rebai; Faiza Fakhfakh; Hammadi Ayadi; Elisabeth Petit-Teixeira; Abdellatif Maalej
Related Documents :
10023049 - Identification of dna polymorphisms associated with the v type alpha1-antitrypsin gene.
21421779 - Targeted allele replacement mutagenesis of corynebacterium pseudotuberculosis.
21548019 - Maternal vitamin d receptor genetic variation contributes to infant birthweight among b...
11150049 - Ancestral proportions and admixture dynamics in geographically defined african american...
19455599 - A sequencing-based survey of functional apaf1 alleles in a large sample of individuals ...
9693029 - Drd2 allele frequencies and linkage disequilibria, including the -141cins/del promoter ...
20145159 - Potential clinical significance of a plasma-based kras mutation analysis in patients wi...
24553179 - Calr exon 9 mutations are somatically acquired events in familial cases of essential th...
25113799 - Embryonic aneuploidy: overcoming molecular genetics challenges improves outcomes and ch...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-18
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  -     ISSN:  0392-856X     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Laboratory of Human Molecular Genetics, Faculty of Medicine, Sfax, Tunisia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  CTLA-4 (CD152) blockade does not cause a pro-inflammatory cytokine profile in regulatory T cells.
Next Document:  Neuropsychological assessment in systemic lupus erythematosus patients: clinical usefulness of first...