Document Detail

Signal recognition particles in chloroplasts, bacteria, yeast and mammals (review).
MedLine Citation:
PMID:  16092520     Owner:  NLM     Status:  MEDLINE    
The Signal Recognition Particle (SRP) plays a critical role in the sorting of nascent secretory and membrane proteins. Remarkably, this function has been conserved from bacteria, where SRP delivers proteins to the inner membrane, through to eukaryotes, where SRP is required for targeting of proteins to the endoplasmic reticulum. This review focuses on present understanding of SRP structure and function and the relationship between the two. Furthermore, the similarities and differences in the structure, function and cellular role of SRP in bacteria, chloroplasts, fungi and mammals will be stressed.
Martin R Pool
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Molecular membrane biology     Volume:  22     ISSN:  0968-7688     ISO Abbreviation:  Mol. Membr. Biol.     Publication Date:    2005 Jan-Apr
Date Detail:
Created Date:  2005-08-11     Completed Date:  2005-09-13     Revised Date:  2014-07-22    
Medline Journal Info:
Nlm Unique ID:  9430797     Medline TA:  Mol Membr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3-15     Citation Subset:  IM    
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MeSH Terms
Bacteria / metabolism
Chloroplasts / metabolism
Mammals / metabolism
Protein Sorting Signals
Protein Structure, Tertiary
Receptors, Cytoplasmic and Nuclear / metabolism
Receptors, Peptide / metabolism
Signal Recognition Particle / chemistry*,  physiology*
Yeasts / metabolism
Grant Support
C20431//Biotechnology and Biological Sciences Research Council
Reg. No./Substance:
0/Protein Sorting Signals; 0/Receptors, Cytoplasmic and Nuclear; 0/Receptors, Peptide; 0/Signal Recognition Particle; 0/signal peptide receptor

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