| Signal-induced functions of the transcription factor TFII-I. | |
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MedLine Citation:
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PMID: 17976384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have learned a great deal over the last several years about the molecular mechanisms that govern cell growth, cell division and cell death. Normal cells pass through cell cycle (growth) and divide in response to mitogenic signals that are transduced through their cognate cell surface receptors to the nucleus. Despite the fact that cellular growth and division are mechanistically distinct steps, they are usually coordinately regulated, which is critical for normal cellular proliferation. The precise mechanistic basis for this coordinated regulation is unclear. TFII-I is a unique, signal-induced multifunctional transcription factor that is activated upon a variety of signaling pathways and appears to participate in distinct phases of cell growth. For instance, TFII-I is required for growth factor-induced transcriptional activation of the c-fos gene, which is essential for cell cycle entry. Two alternatively spliced isoforms of TFII-I exhibit opposing but necessary functions for mitogen-induced transcriptional activation of c-fos. Besides transcriptional activation of the c-fos proto-oncogene and eventual entry into cell cycle, TFII-I also appears to have a role in later phases of the cell cycle and cell division. Here we discuss how a multitude of signaling inputs target TFII-I isoforms, which may exert their functions in distinct phases of the cell cycle and play a key role in the coordinated regulation of cellular proliferation. |
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Authors:
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Ananda L Roy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2007-10-11 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1769 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2007 Nov-Dec |
Date Detail:
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Created Date: 2007-11-20 Completed Date: 2008-01-31 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 613-21 Citation Subset: IM |
Affiliation:
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Department of Pathology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA. ananda.roy@tufts.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle Cell Division Gene Expression Regulation Genes, fos Humans Models, Genetic Protein Isoforms Signal Transduction* Transcription Factors, TFII / physiology* Transcription, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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AI45150/AI/NIAID NIH HHS; HD046034/HD/NICHD NIH HHS; R01 HD046034-04/HD/NICHD NIH HHS; R56 AI045150-06A2/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/GTF2I protein, human; 0/Protein Isoforms; 0/Transcription Factors, TFII |
| Comments/Corrections | |
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