| Signal-averaged ECG prior to and serially after thrombolytic therapy for acute myocardial infarction. | |
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MedLine Citation:
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PMID: 8774817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Signal averaging has been performed to evaluate late potentials following infarction and the administration of thrombolytic therapy. Most studies have recorded signal-averaged electrocardiograms (SAECGs) at least 12 hours after the onset of the infarction. In this study, SAECGs were recorded before thrombolytic therapy and serially over 7-10 days following infarction in 21 patients. The high frequency QRS duration was significantly shortened at 1 and 24 hours compared to presentation (96.8 +/- 11.3 ms and 93.4 +/- 8.0 ms vs 103.3 +/- 14.3 ms, respectively, P < 0.05) and there was an increase in the terminal voltage over time, significant at 1 hour and 3 days (57.3 +/- 29.1 microV and 58.6 +/- 44.7 microV vs 44.4 +/- 35.5 microV, respectively, P < 0.01). Five patients met criteria for ventricular late potentials on at least one SAECG. The prevalence of late potentials was higher in patients with Q wave infarctions, or with occluded infarct related arteries. These changes in myocardial activation may be related to ischemia and reperfusion, and may not correlate with the development of a fixed substrate for reentry. |
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Authors:
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L A Beauregard; H L Waxman; R Volosin; K J Volosin; P B Kurnik |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: 19 ISSN: 0147-8389 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-11-08 Completed Date: 1996-11-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 883-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Cooper Hospital/University Medical Center, UMDNJ/Robert Wood Johnson Medical School, Camden, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Electrocardiography* Female Humans Male Middle Aged Myocardial Infarction / drug therapy, physiopathology* Plasminogen Activators / therapeutic use Prospective Studies Signal Processing, Computer-Assisted Thrombolytic Therapy* Time Factors Tissue Plasminogen Activator / therapeutic use Ventricular Function |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.-/Plasminogen Activators; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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