Document Detail

Signal-averaged ECG prior to and serially after thrombolytic therapy for acute myocardial infarction.
MedLine Citation:
PMID:  8774817     Owner:  NLM     Status:  MEDLINE    
Signal averaging has been performed to evaluate late potentials following infarction and the administration of thrombolytic therapy. Most studies have recorded signal-averaged electrocardiograms (SAECGs) at least 12 hours after the onset of the infarction. In this study, SAECGs were recorded before thrombolytic therapy and serially over 7-10 days following infarction in 21 patients. The high frequency QRS duration was significantly shortened at 1 and 24 hours compared to presentation (96.8 +/- 11.3 ms and 93.4 +/- 8.0 ms vs 103.3 +/- 14.3 ms, respectively, P < 0.05) and there was an increase in the terminal voltage over time, significant at 1 hour and 3 days (57.3 +/- 29.1 microV and 58.6 +/- 44.7 microV vs 44.4 +/- 35.5 microV, respectively, P < 0.01). Five patients met criteria for ventricular late potentials on at least one SAECG. The prevalence of late potentials was higher in patients with Q wave infarctions, or with occluded infarct related arteries. These changes in myocardial activation may be related to ischemia and reperfusion, and may not correlate with the development of a fixed substrate for reentry.
L A Beauregard; H L Waxman; R Volosin; K J Volosin; P B Kurnik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  19     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-11-08     Completed Date:  1996-11-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  883-9     Citation Subset:  IM    
Department of Medicine, Cooper Hospital/University Medical Center, UMDNJ/Robert Wood Johnson Medical School, Camden, USA.
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MeSH Terms
Middle Aged
Myocardial Infarction / drug therapy,  physiopathology*
Plasminogen Activators / therapeutic use
Prospective Studies
Signal Processing, Computer-Assisted
Thrombolytic Therapy*
Time Factors
Tissue Plasminogen Activator / therapeutic use
Ventricular Function
Reg. No./Substance:
EC 3.4.21.-/Plasminogen Activators; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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