Document Detail

Sign-tracking (autoshaping) in rats: a comparison of cocaine and food as unconditioned stimuli.
MedLine Citation:
PMID:  15825887     Owner:  NLM     Status:  MEDLINE    
A series of experiments was performed to determine whether sign-tracking would occur in rats with intravenous (i.v.) cocaine as the unconditioned stimulus. In Experiment 1, a retractable lever paired with food produced strong sign-tracking, but a lever paired with one of three doses of i.v. cocaine did not elicit any approach or contact behavior. Experiment 2 demonstrated that doses of cocaine that did not elicit sign-tracking would function as a positive reinforcer for a lever contact operant. In Experiment 3, an artificial consummatory response was added to make the cocaine reinforcement episode more behaviorally comparable to that occasioned by food. Although the rats readily performed this response when it was required to receive cocaine infusions, they still did not contact a lever that signaled the availability of these infusions. It appears that cocaine is different from other positive reinforcers (e.g., food, water, warmth, or intracranial stimulation) in that it will not produce sign-tracking in rats.
David N Kearns; Stanley J Weiss
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Learning & behavior     Volume:  32     ISSN:  1543-4494     ISO Abbreviation:  Learn Behav     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2005-04-13     Completed Date:  2005-07-08     Revised Date:  2011-01-24    
Medline Journal Info:
Nlm Unique ID:  101155056     Medline TA:  Learn Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  463-76     Citation Subset:  IM    
Department of Psychology, American University, Washington, DC 20016, USA.
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MeSH Terms
Animal Feed*
Appetitive Behavior
Association Learning*
Cocaine* / pharmacology
Conditioning, Classical*
Consummatory Behavior
Dose-Response Relationship, Drug
Infusions, Intravenous
Rats, Long-Evans
Reinforcement (Psychology)
Self Administration
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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