| Sign-dependent changes in retinal electrical activity with positive and negative defocus in the human eye. | |
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MedLine Citation:
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PMID: 22100834 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The purpose of this study was to investigate the effect of optical defocus on changes of electrical response as a function of retinal region. Twenty-three subjects (aged 19-25year) with normal ocular health were recruited for global flash multifocal electroretinogram (mfERG) recordings under control (fully corrected) condition, and short-term positive defocus (+2D and +4D) and negative defocus (-2D and -4D) conditions. The amplitudes and implicit times of direct (DC) and induced (IC) components of mfERG responses were pooled into six concentric rings for analyses. The mfERG responses demonstrated more significant changes in amplitude in paracentral retinal regions than in the central regions under defocused conditions. The paracentral DC amplitude showed a significant reduction under negative defocus conditions. In contrast, the paracentral IC amplitude showed a significant increment under positive defocus conditions. Interestingly, the central IC response showed significant reduction in amplitude only to negative defocus, while increasing its amplitude to positive defocus. However, the DC and IC implicit times were virtually unaffected under defocused conditions. Our findings suggest that human retina is able to differentiate defocused signals and to identify positive and negative defocus. It shows that paracentral retina reacts more vigorously to optical defocus than does central retina. |
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Authors:
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Wing-Cheung Ho; On-Ying Wong; Yuen-Chi Chan; Sze-Wai Wong; Chea-Su Kee; Henry Ho-Lung Chan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-12 |
Journal Detail:
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Title: Vision research Volume: - ISSN: 1878-5646 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417402 Medline TA: Vision Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
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Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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