Document Detail

Sigma receptors: potential targets for a new class of antidepressant drug.
MedLine Citation:
PMID:  20438757     Owner:  NLM     Status:  MEDLINE    
Despite the widespread and devastating impact of depression on society, our current understanding of its pathogenesis is limited. Likewise, existing treatments are inadequate, providing relief to only a subset of people suffering from depression. The search for more effective antidepressant drugs includes the investigation of new molecular targets. Among them, current data suggests that sigma receptors are involved in multiple processes effecting antidepressant-like actions in vivo and in vitro. This review summarizes accumulated evidence supporting a role for sigma receptors in antidepressant effects and provides a conceptual framework for delineating their potential roles over the course of antidepressant treatment.
James A Fishback; Matthew J Robson; Yan-Tong Xu; Rae R Matsumoto
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-05-11
Journal Detail:
Title:  Pharmacology & therapeutics     Volume:  127     ISSN:  1879-016X     ISO Abbreviation:  Pharmacol. Ther.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-06     Completed Date:  2010-11-22     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  7905840     Medline TA:  Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  271-82     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Antidepressive Agents* / pharmacology,  therapeutic use
Depression / drug therapy*,  metabolism
Drug Design*
Receptors, Neurotransmitter / metabolism
Receptors, sigma / agonists,  physiology*
Signal Transduction / drug effects
Grant Support
R01 DA011979/DA/NIDA NIH HHS; R01 DA011979-01A2/DA/NIDA NIH HHS; R01 DA013978/DA/NIDA NIH HHS; R01 DA013978-01A1/DA/NIDA NIH HHS
Reg. No./Substance:
0/Antidepressive Agents; 0/Receptors, Neurotransmitter; 0/Receptors, sigma

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