Document Detail


Siglecs in innate immunity.
MedLine Citation:
PMID:  15955740     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Siglecs are sialic acid-binding Ig-like lectins expressed in a highly specific manner, and which are implicated in signaling and adhesive functions. The CD33-related siglecs represent a distinct subgroup that is undergoing rapid evolution within the innate immune system, with the potential to trigger apoptosis and provide inhibitory signals. CD22 is a well-characterised B cell restricted siglec that has been shown to mediate both sialic acid-dependent and -independent signaling functions in B cell regulation. As endocytic receptors, siglecs provide portals of entry for certain viral and bacterial pathogens, as well as therapeutic opportunities for targeting innate immune cells in disease.
Authors:
Paul R Crocker
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  5     ISSN:  1471-4892     ISO Abbreviation:  Curr Opin Pharmacol     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-06     Completed Date:  2006-05-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  431-7     Citation Subset:  IM    
Affiliation:
Division of Cell Biology and Immunology, The Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, UK. p.r.crocker@dundee.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD / genetics,  immunology
Antigens, CD22 / genetics,  immunology
Antigens, Differentiation, Myelomonocytic / genetics,  immunology
Apoptosis / genetics,  immunology
Evolution, Molecular
Humans
Immunity, Innate / genetics,  immunology*
Lectins / genetics,  immunology*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD22; 0/Antigens, Differentiation, Myelomonocytic; 0/CD33 antigen; 0/Lectins; 0/sialic acid binding Ig-like lectin

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