Document Detail


Siglec-6 expression is increased in placentas from pregnancies complicated by preterm preeclampsia.
MedLine Citation:
PMID:  23171684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sialic acid immunoglobulin-like lectin (Siglec)-6 is a transmembrane receptor that binds sialyl-TN glycans and leptin. Among eutherian mammals, only human placentas express Siglec-6. Previous work has implicated Siglec-6 in preeclampsia (PE). Preeclampsia, a leading cause of maternal and perinatal morbidity and mortality, is characterized by placental abnormalities. This study provides a comprehensive analysis of Siglec-6 protein expression during human pregnancy by disease state (PE), biologic compartment (basal plate, chorionic villi, or maternal plasma), gestational age (24-41 weeks), and labor status. Siglec-6 protein was increased in both the basal plate and chorionic villi of preterm PE placentas (P < .05). However, expression did not differ at term by disease state, compartment, or labor status. Siglec-6 was not detectable in maternal serum. Overexpression of Siglec-6 protein in preterm PE placentas may contribute to or represent a response to PE pathogenesis and suggests that preterm PE pathogenesis is distinct from term PE.
Authors:
Kristen K Rumer; Jill Uyenishi; M Camille Hoffman; Barbra M Fisher; Virginia D Winn
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-20
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  20     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-08     Completed Date:  2013-11-25     Revised Date:  2013-12-16    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  646-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD / blood,  genetics,  metabolism*
Antigens, Differentiation, Myelomonocytic / blood,  genetics,  metabolism*
Case-Control Studies
Cell Line, Tumor
Female
Gestational Age
Humans
Labor, Obstetric
Lectins / blood,  genetics,  metabolism*
Placenta / metabolism*
Pre-Eclampsia / blood,  metabolism*
Pregnancy
Premature Birth
Transfection
Trophoblasts / metabolism
Up-Regulation
Grant Support
ID/Acronym/Agency:
K12 HD001271/HD/NICHD NIH HHS; R01 HD060723/HD/NICHD NIH HHS; R01 HD060723/HD/NICHD NIH HHS; TL1 RR025778/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/Lectins; 0/SIGLEC6 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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