Document Detail

Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes.
MedLine Citation:
PMID:  19185988     Owner:  NLM     Status:  MEDLINE    
To characterize the biological features of side population (SP) in oral squamous cell carcinoma (OCC), SP and non-SP were sorted and compared. The SP cells were more clonogenic and in nude mice, only 10,000 SP cells were needed for tumor development compared to 1,000,000 non-SP cells. The SP cells expressed higher levels of ABCG2, ABCB1, CD44, Oct-4, Bmi-1, NSPc1 and CK19. The SP cells generated SP and non-SP populations, whereas the non-SP cells generated only non-SP. These findings provide the first evidence that SP in OCC possesses tumor stem cell phenotypes and may play an important role in OCC tumorigenesis.
Ping Zhang; Yan Zhang; Li Mao; Zhiyuan Zhang; Wantao Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-30
Journal Detail:
Title:  Cancer letters     Volume:  277     ISSN:  1872-7980     ISO Abbreviation:  Cancer Lett.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  227-34     Citation Subset:  IM    
Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, School of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, China.
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MeSH Terms
Antigens, Differentiation / metabolism
Carcinoma, Squamous Cell / metabolism,  pathology*
Cell Cycle / physiology
Cell Line, Tumor
Cell Proliferation
Cell Transformation, Neoplastic / pathology*
Head and Neck Neoplasms / metabolism,  pathology*
Mice, Inbred BALB C
Mice, Nude
Neoplasm Proteins / metabolism
Neoplasm Transplantation
Neoplastic Stem Cells / metabolism,  pathology*
Transplantation, Heterologous
Reg. No./Substance:
0/Antigens, Differentiation; 0/Neoplasm Proteins

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