Document Detail

Side effects with amiodarone therapy.
MedLine Citation:
PMID:  7937427     Owner:  NLM     Status:  MEDLINE    
Amiodarone hydrochloride is increasingly being used in the treatment of ventricular and supraventricular arrhythmias. Although a highly effective anti-arrhythmic agent, its use is restricted by the high incidence of side effects. To elucidate the value of monitoring serum level of both the parent drug and its active metabolite in predicting the occurrence of side effects, the investigators examined 109 patients from a register of patients treated with amiodarone for the prevalence of known side effects of the drug. The register contained over 90% of patients treated with amiodarone at the Leicester General Hospital during the period of the study. The findings suggest cutaneous side effects and abnormal thyroid function tests (without overt gland dysfunction) are more likely to occur with increasing duration of treatment and cumulative dosage. However, neither the serum amiodarone level nor the serum metabolite level had any predictive power for the occurrence of side effects. In view of this finding, it is recommended that close attention be paid to the continued clinical monitoring of side effects and that there is utility in measuring the serum amiodarone level in each patient to avoid the prescription of unnecessarily high doses. This is necessary not only to lessen the occurrence of cumulative dose-related side effects, but also because the variable but very long half-life of the drug leads to difficulties in relating spot drug levels to long-term effects.
R Shukla; N I Jowett; D R Thompson; J E Pohl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  70     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-10-26     Completed Date:  1994-10-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  492-8     Citation Subset:  IM    
Department of Medicine, Leicester General Hospital, UK.
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MeSH Terms
Amiodarone / administration & dosage,  adverse effects*,  blood
Drug Administration Schedule
Drug Eruptions / etiology
Middle Aged
Nervous System Diseases / chemically induced
Photosensitivity Disorders / chemically induced
Tachycardia / blood,  drug therapy*
Thyroid Diseases / chemically induced
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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