Document Detail

Side effects of therapy with prostaglandin E1 in infants with critical congenital heart disease.
MedLine Citation:
PMID:  7285304     Owner:  NLM     Status:  MEDLINE    
The case reports of 492 infants with critical congenital cardiac disease treated with prostaglandin E1 (PGE1) were reviewed to determine the nature and incidence of intercurrent medical events. Forty-three percent of the infants had at least one such event, but only half of these were related to PGE1 and the majority required only minor changes in management. Cardiovascular events were the most common (18% incidence), with cutaneous vasodilation and edema occurring more frequently during intraaortic infusion than during i.v. infusion. Central nervous system events were reported in 16% of the patients. Respiratory depression was reported in 12%, and was particularly common in infants weighing less than 2.0 kg at birth (42%). Hematologic, infectious and renal events appeared for the most part to be unrelated to PGE1. The overall mortality (excluding 19 patients with hypoplastic left-heart syndrome) was 31%; the mortality for the patients with critical coarctation or interruption of the aortic arch was nearly twice that for the cyanotic infants (50% vs 27%). No death was attributed to PGE1 administration. During infusion of PGE1, arterial blood pressure and respiratory activity should be monitored carefully and appropriate supportive steps taken if hypotension or respiratory depression occurs. The development of fever or jitteriness may require reduction of the infusion rate and, in view of the possible increased incidence of infections, the prophylactic use of antibiotics is recommended.
A B Lewis; M D Freed; M A Heymann; S L Roehl; R C Kensey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  64     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1981-12-15     Completed Date:  1981-12-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  893-8     Citation Subset:  AIM; IM    
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MeSH Terms
Bacterial Infections / chemically induced
Cardiovascular System / drug effects
Central Nervous System / drug effects
Cyanosis / complications
Diarrhea, Infantile / chemically induced
Disseminated Intravascular Coagulation / chemically induced
Heart Defects, Congenital / complications,  drug therapy*,  mortality
Hypocalcemia / chemically induced
Hypoglycemia / chemically induced
Infant, Newborn
Prostaglandins E / adverse effects,  therapeutic use*
Respiration / drug effects
Reg. No./Substance:
0/Prostaglandins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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