| Side effects of minocycline treatment in patients with fragile X syndrome and exploration of outcome measures. | |
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MedLine Citation:
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PMID: 20687826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Minocycline can rescue the dendritic spine and synaptic structural abnormalities in the fragile X knock-out mouse. This is a review and preliminary survey to document side effects and potential outcome measures for minocycline use in the treatment of individuals with fragile X syndrome. We surveyed 50 patients with fragile X syndrome who received minocycline for at least 2 weeks and found that the most common reported side effect is gastrointestinal difficulty, including loss of appetite. The families reported an improvement in language and behavioral areas. Outcome measures in the design of future randomized clinical trials should include both behavioral and language measures. As with any other treatments, we emphasize that randomized clinical trials are needed to determine the efficacy of minocycline in fragile X syndrome. |
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Authors:
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Agustini Utari; Weerasak Chonchaiya; Susan M Rivera; Andrea Schneider; Randi J Hagerman; Sultana M H Faradz; Iryna M Ethell; Danh V Nguyen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal on intellectual and developmental disabilities Volume: 115 ISSN: 1944-7515 ISO Abbreviation: Am J Intellect Dev Disabil Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-06 Completed Date: 2010-10-25 Revised Date: 2011-02-18 |
Medline Journal Info:
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Nlm Unique ID: 101492916 Medline TA: Am J Intellect Dev Disabil Country: United States |
Other Details:
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Languages: eng Pagination: 433-43 Citation Subset: IM |
Affiliation:
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M.I.N.D. Institute, University of California at Davis Medical Center, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anti-Bacterial Agents / adverse effects*, therapeutic use Child Child Behavior Disorders / diagnosis, drug therapy Child, Preschool Female Follow-Up Studies Fragile X Syndrome / diagnosis, drug therapy* Humans Infant Language Development Disorders / diagnosis, drug therapy Male Minocycline / adverse effects*, therapeutic use Neuroprotective Agents / adverse effects*, therapeutic use Randomized Controlled Trials as Topic Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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90DD05969/DD/NCBDD CDC HHS; HD02274/HD/NICHD NIH HHS; HD036071/HD/NICHD NIH HHS; R01 HD036071-13/HD/NICHD NIH HHS; UL1 RR024146/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Neuroprotective Agents; 10118-90-8/Minocycline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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