Document Detail

Side effects of laser therapy, modified by ultraviolet irradiation and para-aminobenzoic acid in mice.
MedLine Citation:
PMID:  8471142     Owner:  NLM     Status:  MEDLINE    
Scarring is a well-known side-effect of cutaneous laser treatment and exposure to solar ultraviolet radiation is suspected to increase scar formation. We investigated how wounds and scarring were modified by interfering in the laser-induced inflammation using ultraviolet radiation and para-aminobenzoic acid. A copper vapour laser operating at 578 nm was used at three different intensities and doses. The ultraviolet radiation was administered three times weekly prior to and four times weekly after the laser treatment. The daily dose was 21.5 kJ/m2 equivalent to 3.5 Basic-MED. The laser-induced wounds were evaluated daily and histological and biochemical analyses were used to estimate scarring. Ultraviolet irradiation resulted at some of the used laser intensities in decreased scores of maximum wound area, wound healing time, cumulated wound area, and a decreased skin content of hydroxyproline, whereas the degree of the chronic fibrosis tended to increase. Application of para-aminobenzoic acid before the solar ultraviolet irradiation did not change the acute wound scores but reduced, although not significantly, the degree of fibrosis.
M Haedersdal; T Poulsen; H C Wulf
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  19     ISSN:  0305-4179     ISO Abbreviation:  Burns     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-18     Completed Date:  1993-05-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Department of Dermatology, Copenhagen University Hospital, Rigshospitalet, Denmark.
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MeSH Terms
4-Aminobenzoic Acid / pharmacology*,  therapeutic use
Cicatrix / etiology,  prevention & control
Hydroxylysine / analysis
Hydroxyproline / analysis
Laser Therapy
Lasers / adverse effects*
Mice, Hairless
Skin / chemistry,  injuries*,  pathology
Ultraviolet Rays / adverse effects*
Wound Healing* / drug effects,  radiation effects
Reg. No./Substance:
150-13-0/4-Aminobenzoic Acid; 28902-93-4/Hydroxylysine; 51-35-4/Hydroxyproline

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