| Side effects from the pulsed dye laser: the importance of skin pigmentation and skin redness. | |
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MedLine Citation:
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PMID: 9833046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pulsed dye laser is the treatment of choice for port-wine stains. In this study we evaluate the importance of preoperative skin pigmentation and skin redness for the development of side effects from one treatment with the pulsed dye laser. A risk assessment is performed and skin reflectance measurement objectifies postoperative pigmentary changes. Fourteen human volunteers (skin types I to V) were laser-treated on the inside of the proximal brachium. Photographic documentation was used for blinded, clinical evaluation of side effects 3 and 6 months postoperatively. Skin was artificially reddened using topical application of 10% nicotinic acid cream. The development of pigmentary alterations and texture changes depended on the preoperative pigmentation and redness degrees. The risk of inducing clinically visible pigmentary alterations and texture changes increased with higher preoperative skin pigmentation and redness degrees, and with the application of increasing laser doses. Pigmentary alterations were induced at a lower fluence level than texture changes. The risk of side effects was higher 3 months postoperatively than 6 months postoperatively, substantiating a gradual disappearance of side effects. Skin reflectance measurements documented postoperative hyperpigmentation that faded partially from 3 to 6 months postoperatively. This is the first human experimental model for port-wine stains which provides quantitative data on the relationship between preoperative skin colours and postoperative clinically disturbing side effects. |
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Authors:
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M Haedersdal; M Gniadecka; J Efsen; N Bech-Thomsen; J Keiding; H C Wulf |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 78 ISSN: 0001-5555 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-02-04 Completed Date: 1999-02-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 445-50 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Adult Color Female Follow-Up Studies Humans Hyperpigmentation / etiology Laser Coagulation / adverse effects* Male Middle Aged Niacin / administration & dosage, pharmacology Photography Pigmentation Disorders / etiology Placebos Port-Wine Stain / pathology, surgery Risk Assessment Risk Factors Single-Blind Method Skin / drug effects, pathology* Skin Pigmentation / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Placebos; 59-67-6/Niacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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