Document Detail

Side-effects of fluoride therapy.
MedLine Citation:
PMID:  2070428     Owner:  NLM     Status:  MEDLINE    
Fluoride stimulates bone formation and is used in the treatment of vertebral osteoporosis. Epidemiological and experimental studies have shown that fluoride bone is denser but not always stronger than normal bone, and the main side-effects attributed to this drug involve bone tissue. True fractures, with cortical rupture, are few (near 5%); their rate seems to correspond to that generally found in osteoporotic patients without treatment. On the other hand, stress fractures and arthralgia of the lower limbs are much more frequent (near 30%), but they often follow a benign course. Digestive tolerance of fluoride is now good, improved by the introduction of gastro-resistant industrial galenicals. However, the question of whether the risk/benefit ratio is positive is always under discussion.
M Laroche; B Mazières
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Baillière's clinical rheumatology     Volume:  5     ISSN:  0950-3579     ISO Abbreviation:  Baillieres Clin Rheumatol     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-08-20     Completed Date:  1991-08-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8805770     Medline TA:  Baillieres Clin Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  61-76     Citation Subset:  IM    
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MeSH Terms
Bone and Bones / drug effects*
Fluorides / adverse effects*,  therapeutic use
Fractures, Bone / chemically induced
Gastrointestinal Diseases / chemically induced
Osteoporosis / drug therapy
Reg. No./Substance:

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