| Side effects of cardiopulmonary bypass: what is the reality? | |
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MedLine Citation:
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PMID: 15548178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite many years of clinical and experimental research, the contribution of cardiopulmonary bypass (CPB) and cardioplegic arrest to morbidity and mortality following cardiac surgery remains unclear. This is due, in part, to lack of suitable control group against which bypass and cardioplegic arrest can be compared. The recent success of beating heart coronary artery bypass grafting has, however, for the first time, provided an opportunity to compare the same operation, in similar patient groups, with, or without CPB and cardioplegic arrest. CPB is associated with an acute phase reaction of protease cascades, leucocyte, and platelet activation that result in tissue injury. This is largely manifest as subclinical organ dysfunction that produces a clinical effect in those patients that generate an excessive inflammatory response or in those with limited functional reserve. The contribution of myocardial ischemia/reperfusion, secondary to aortic cross-clamping, and cardioplegic arrest, to the systemic inflammatory response and wider organ dysfunction is unknown, and requires further evaluation in clinical trials. |
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Authors:
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G J Murphy; G D Angelini |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of cardiac surgery Volume: 19 ISSN: 0886-0440 ISO Abbreviation: J Card Surg Publication Date: 2004 Nov-Dec |
Date Detail:
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Created Date: 2004-11-19 Completed Date: 2006-08-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8908809 Medline TA: J Card Surg Country: United States |
Other Details:
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Languages: eng Pagination: 481-8 Citation Subset: IM |
Affiliation:
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Bristol Heart Institute, University of Bristol, Bristol, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiopulmonary Bypass
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adverse effects* Clinical Trials as Topic Coronary Artery Bypass, Off-Pump / adverse effects Cytokines / metabolism Humans Inflammation Mediators / metabolism Multiple Organ Failure / etiology, metabolism Myocardial Reperfusion Injury / etiology, metabolism Postoperative Complications / etiology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Inflammation Mediators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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