Document Detail

Side-effects of antituberculosis drug treatment in patients with chronic renal failure.
MedLine Citation:
PMID:  12212979     Owner:  NLM     Status:  MEDLINE    
Patients with chronic renal failure (CRF) have a high incidence of tuberculosis (TB). Those from the Indian subcontinent are at particular risk. The frequency of side-effects associated with antituberculous treatment in a group of patients with CRF was studied. All cases of TB in patients with CRF occurring over a 13-yr period at the Manchester Royal Infirmary, from 1986-1999, were identified by diagnostic coding, microbiology records and a TB database. The case notes were then reviewed. Twenty-four cases were identified, eight predialysis and 16 requiring regular dialysis. TB occurring in the dialysis group was extrapulmonary in every case. Nineteen of 24 (79%) patients were of Indian subcontinent origin and 14 of 16 (87%) dialysis patients were non-Caucasian. Adverse effects of treatment occurred in two of eight (25%) in the predialysis group and nine of 16 (56%) of the dialysis group. These were most commonly neuropsychiatric (6), hepatic (4) and gastrointestinal (4). Neuropsychiatric symptoms occurred exclusively in dialysis patients. In conclusion, a high incidence of side-effects from antituberculous medication, especially neuropsychiatric, hepatic and gastrointestinal, was identified in patients with chronic renal failure. Careful monitoring for side-effects is essential in this group, and consideration should be given to administering antituberculous chemoprophylaxis to all high-risk groups.
S J Quantrill; M A Woodhead; C E Bell; C C Hardy; A J Hutchison; R Gokal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  20     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-09-05     Completed Date:  2003-01-14     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  440-3     Citation Subset:  IM    
Dept of Respiratory Medicine, Manchester Royal Infirmary, UK.
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MeSH Terms
Antitubercular Agents / adverse effects*,  therapeutic use*
Drug-Induced Liver Injury*
Gastrointestinal Diseases / chemically induced*,  ethnology
India / ethnology
Kidney Failure, Chronic / complications*,  ethnology
Liver Diseases / ethnology
Middle Aged
Nervous System Diseases / chemically induced*,  ethnology
Retrospective Studies
Time Factors
Tuberculosis / drug therapy*,  ethnology,  etiology*
Reg. No./Substance:
0/Antitubercular Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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