Document Detail


Side-effects of antituberculosis drug treatment in patients with chronic renal failure.
MedLine Citation:
PMID:  12212979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with chronic renal failure (CRF) have a high incidence of tuberculosis (TB). Those from the Indian subcontinent are at particular risk. The frequency of side-effects associated with antituberculous treatment in a group of patients with CRF was studied. All cases of TB in patients with CRF occurring over a 13-yr period at the Manchester Royal Infirmary, from 1986-1999, were identified by diagnostic coding, microbiology records and a TB database. The case notes were then reviewed. Twenty-four cases were identified, eight predialysis and 16 requiring regular dialysis. TB occurring in the dialysis group was extrapulmonary in every case. Nineteen of 24 (79%) patients were of Indian subcontinent origin and 14 of 16 (87%) dialysis patients were non-Caucasian. Adverse effects of treatment occurred in two of eight (25%) in the predialysis group and nine of 16 (56%) of the dialysis group. These were most commonly neuropsychiatric (6), hepatic (4) and gastrointestinal (4). Neuropsychiatric symptoms occurred exclusively in dialysis patients. In conclusion, a high incidence of side-effects from antituberculous medication, especially neuropsychiatric, hepatic and gastrointestinal, was identified in patients with chronic renal failure. Careful monitoring for side-effects is essential in this group, and consideration should be given to administering antituberculous chemoprophylaxis to all high-risk groups.
Authors:
S J Quantrill; M A Woodhead; C E Bell; C C Hardy; A J Hutchison; R Gokal
Related Documents :
16567269 - Menu suggestion: an effective way to improve dietary compliance in peritoneal dialysis ...
11466669 - Patients' experiences of a dialysis diet and their implications for the role of the die...
884909 - Dialysis in the treatment of renal failure in patients with liver disease.
20720499 - Blood pressure and survival in long-term hemodialysis patients with and without polycys...
20370459 - When is dialysis indicated in acute kidney injury?
1415359 - Whole blood serotonin levels are markedly elevated in patients on dialytic therapy.
7350049 - Chronic diarrhea of unknown origin.
18791549 - Retinal microstructure in patients with efemp1 retinal dystrophy evaluated by fourier d...
11889959 - Clinical evaluation of disorganization during atrial fibrillation as a guide to radiofr...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  20     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-09-05     Completed Date:  2003-01-14     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  440-3     Citation Subset:  IM    
Affiliation:
Dept of Respiratory Medicine, Manchester Royal Infirmary, UK. s.quantrill@ic.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antitubercular Agents / adverse effects*,  therapeutic use*
Drug-Induced Liver Injury*
Female
Gastrointestinal Diseases / chemically induced*,  ethnology
Humans
India / ethnology
Kidney Failure, Chronic / complications*,  ethnology
Liver Diseases / ethnology
Male
Middle Aged
Nervous System Diseases / chemically induced*,  ethnology
Retrospective Studies
Time Factors
Tuberculosis / drug therapy*,  ethnology,  etiology*
Chemical
Reg. No./Substance:
0/Antitubercular Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hospital-acquired pneumonia: microbiological data and potential adequacy of antimicrobial regimens.
Next Document:  Some factors affecting cerebral tissue saturation during obstructive sleep apnoea.