| Side effects of anabolic androgenic steroids: pathological findings and structure-activity relationships. | |
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MedLine Citation:
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PMID: 20020376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Side effects of anabolic steroids with relevance in forensic medicine are mainly due to life-threatening health risks with potential fatal outcome and cases of uncertain limitations of criminal liability after steroid administration. Both problems are typically associated with long-term abuse and excessive overdose of anabolic steroids. Side effects may be due to direct genomic or nongenomic activities (myotrophic, hepatotoxic), can result from down-regulation of endogenous biosynthesis (antiandrogenic) or be indirect consequence of steroid biotransformation (estrogenic).Logically, there are no systematic clinical studies available and the number of causally determined fatalities is fairly limited. The following compilation reviews typical abundant observations in cases where nonnatural deaths (mostly liver failure and sudden cardiac death) were concurrent with steroid abuse. Moreover, frequent associations between structural characteristics and typical side effects are summarized. |
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Authors:
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Andreas B?ttner; Detlef Thieme |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Handbook of experimental pharmacology Volume: - ISSN: 0171-2004 ISO Abbreviation: Handb Exp Pharmacol Publication Date: 2010 |
Date Detail:
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Created Date: 2009-12-18 Completed Date: 2010-02-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902231 Medline TA: Handb Exp Pharmacol Country: Germany |
Other Details:
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Languages: eng Pagination: 459-84 Citation Subset: IM |
Affiliation:
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Institute of Legal Medicine, St.-Georg-Str. 108, 18055, Rostock, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anabolic Agents
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adverse effects*,
chemistry,
metabolism,
pharmacology Androgens / adverse effects*, chemistry, metabolism, pharmacology Biotransformation Doping in Sports* Humans Mental Disorders / chemically induced, psychology Psychoses, Substance-Induced / psychology Steroids / adverse effects*, chemistry, metabolism, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anabolic Agents; 0/Androgens; 0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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