| Side effects of the addition of clonidine 75 microg or sufentanil 5 microg to 0.2% ropivacaine for labour epidural analgesia. | |
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MedLine Citation:
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PMID: 20202819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Sufentanil 5 microg and clonidine 75 microg produce a similar reduction in minimum local anaesthetic concentration of ropivacaine. The aim of the present study was to compare the side effects of two equianalgesic solutions by combining 0.2% ropivacaine with either sufentanil 5 microg or clonidine 75 microg for labour epidural analgesia. METHODS: In a prospective double-blind study, 60 women at 5 cm cervical dilatation were randomly allocated to receive 0.2% ropivacaine with either sufentanil 5 microg or clonidine 75 microg to initiate labour analgesia. The analgesic efficacy and side effects of the two mixtures were compared. RESULTS: Onset, duration and quality of analgesia and subsequent ropivacaine consumption were similar in the two groups. Hypotension was significantly more frequent and severe with clonidine than with sufentanil (systolic blood pressure <100 mmHg: 17/26 vs. 6/24, P <0.05; systolic blood pressure <90 mmHg: 5/26 vs. 0/24, P <0.05) resulting in more frequent ephedrine administration (11/26 vs. 2/24, P <0.05) and larger fluid requirements (1696 +/- 583 mL vs. 1264 +/- 407 mL, P < 0.05). Conversely, pruritus was more frequent with sufentanil than with clonidine (6/26 vs. 1/24, P <0.05). CONCLUSIONS: Hypotension occurs more frequently when clonidine is added to epidural ropivacaine instead of an equianalgesic dose of sufentanil. Therefore, clonidine cannot be recommended for routine administration for labour epidural analgesia. |
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Authors:
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P Y Dewandre; V Decurninge; V Bonhomme; P Hans; J F Brichant |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-03-03 |
Journal Detail:
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Title: International journal of obstetric anesthesia Volume: 19 ISSN: 1532-3374 ISO Abbreviation: Int J Obstet Anesth Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-29 Completed Date: 2010-12-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200430 Medline TA: Int J Obstet Anesth Country: Netherlands |
Other Details:
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Languages: eng Pagination: 149-54 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Anaesthesia and Intensive Care Medicine, CHR de la Citadelle, Liege University Hospital, Liege, Belgium. pydewandre@chu.ulg.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amides / administration & dosage Analgesia, Epidural / methods* Analgesics / administration & dosage, adverse effects* Anesthesia, Obstetrical / methods* Anesthetics, Local / administration & dosage Clonidine / administration & dosage, adverse effects* Double-Blind Method Female Fluid Therapy Humans Pregnancy Prospective Studies Pruritus / chemically induced Sufentanil / administration & dosage, adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Analgesics; 0/Anesthetics, Local; 4205-90-7/Clonidine; 56030-54-7/Sufentanil; 84057-95-4/ropivacaine |
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