Document Detail

Side-effects of L-dopa on venous tone in Parkinson's disease: a leg-weighing assessment.
MedLine Citation:
PMID:  16302846     Owner:  NLM     Status:  MEDLINE    
In the present study, the effects of L-dopa treatment on cardiovascular variables and peripheral venous tone were assessed in 13 patients with Parkinson's disease (PD) with Hoehn and Yahr stages 1-4. Patients were investigated once with their regular treatment and once after 12 h of interruption of L-dopa treatment. L-Dopa intake significantly reduced systolic and diastolic blood pressure, heart rate and plasma noradrenaline and adrenaline in both the supine and upright (60 degrees ) positions. A significant reduction in stroke volume and cardiac output was also seen with L-dopa. The vascular status of the legs was assessed through thigh compression during leg weighing, a new technique developed in our laboratory. Healthy subjects were used to demonstrate that this technique provided reproducible results, consistent with those provided by strain gauge plethysmography of the calf. When using this technique in patients with PD, L-dopa caused a significant lowering of vascular tone in the lower limbs as shown, in particular, by an increase in venous distensibility. Combined with the results of the orthostatic tilting, these findings support that the treatment-linked lowering of plasma noradrenaline in patients with PD was concomitant with a significant reduction in blood pressure, heart rate and vascular tone in the lower limbs. These pharmacological side-effects contributed to reduce venous return and arterial blood pressure which, together with a lowered heart rate, worsened the haemodynamic status.
Jean-Pierre Wolf; Malika Bouhaddi; Francis Louisy; Andrei Mikehiev; Laurent Mourot; Sylvie Cappelle; Fabrice Vuillier; Pierre Andre; Lucien Rumbach; Jacques Regnard
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  110     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-08     Completed Date:  2006-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  369-77     Citation Subset:  IM    
Physiologie, Faculté de Médecine and UPRES EA 3920 - IFR 133, Université de Franche Comté, F-25030 Besançon, France.
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MeSH Terms
Antiparkinson Agents / adverse effects*
Blood Pressure / drug effects
Cardiac Output / drug effects
Dopamine Agents
Epinephrine / blood
Heart Rate / drug effects
Leg / blood supply*,  pathology
Levodopa / adverse effects*
Middle Aged
Norepinephrine / blood
Organ Size / drug effects
Parkinson Disease / blood,  drug therapy*,  physiopathology
Reproducibility of Results
Tilt-Table Test
Reg. No./Substance:
0/Antiparkinson Agents; 0/Dopamine Agents; 0/Levodopa; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

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