| Side chain modifications of (indol-3-yl)glyoxamides as antitumor agents. | |
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MedLine Citation:
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PMID: 18821257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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New series of analogues of N-(pyridin-4-yl)-2-[1-(4-chlorobenzyl)-indol-3-yl]glyoxamide D-24851 were synthesized, characterized and tested for their in vitro anticancer properties. In the first series, an amino acid spacer was introduced in the glyoxamide chain of D-24851. In the second series, the glyoxamide chain was moved to positions 4 and 5 of indole skeleton. These new compounds were tested on four cancer cell lines (KB, SK-OV-3, NCI-H460 and SF-268), with promising activity for the glycine derivative. |
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Authors:
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Maud Antoine; Pascal Marchand; Guillaume Le Baut; Michael Czech; Silke Baasner; Eckhard Gunther |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of enzyme inhibition and medicinal chemistry Volume: 23 ISSN: 1475-6374 ISO Abbreviation: J Enzyme Inhib Med Chem Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-29 Completed Date: 2008-12-31 Revised Date: 2011-11-07 |
Medline Journal Info:
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Nlm Unique ID: 101150203 Medline TA: J Enzyme Inhib Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 686-95 Citation Subset: IM |
Affiliation:
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Département de Pharmacochimie, Faculté de Pharmacie, Nantes Université, Nantes, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetamides
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chemistry*,
pharmacology* Antineoplastic Agents / chemical synthesis*, pharmacology Cell Line, Tumor Glycine Humans Indoles / chemistry*, pharmacology* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Acetamides; 0/Antineoplastic Agents; 0/Indoles; 0/N-(pyridin-4-yl)-(1-(4-chlorobenzyl)indol-3-yl)glyoxylamide; 56-40-6/Glycine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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