Document Detail


Side chain modifications of (indol-3-yl)glyoxamides as antitumor agents.
MedLine Citation:
PMID:  18821257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
New series of analogues of N-(pyridin-4-yl)-2-[1-(4-chlorobenzyl)-indol-3-yl]glyoxamide D-24851 were synthesized, characterized and tested for their in vitro anticancer properties. In the first series, an amino acid spacer was introduced in the glyoxamide chain of D-24851. In the second series, the glyoxamide chain was moved to positions 4 and 5 of indole skeleton. These new compounds were tested on four cancer cell lines (KB, SK-OV-3, NCI-H460 and SF-268), with promising activity for the glycine derivative.
Authors:
Maud Antoine; Pascal Marchand; Guillaume Le Baut; Michael Czech; Silke Baasner; Eckhard Gunther
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of enzyme inhibition and medicinal chemistry     Volume:  23     ISSN:  1475-6374     ISO Abbreviation:  J Enzyme Inhib Med Chem     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-29     Completed Date:  2008-12-31     Revised Date:  2011-11-07    
Medline Journal Info:
Nlm Unique ID:  101150203     Medline TA:  J Enzyme Inhib Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  686-95     Citation Subset:  IM    
Affiliation:
Département de Pharmacochimie, Faculté de Pharmacie, Nantes Université, Nantes, France.
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MeSH Terms
Descriptor/Qualifier:
Acetamides / chemistry*,  pharmacology*
Antineoplastic Agents / chemical synthesis*,  pharmacology
Cell Line, Tumor
Glycine
Humans
Indoles / chemistry*,  pharmacology*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Acetamides; 0/Antineoplastic Agents; 0/Indoles; 0/N-(pyridin-4-yl)-(1-(4-chlorobenzyl)indol-3-yl)glyoxylamide; 56-40-6/Glycine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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