Document Detail


Side-by-side comparison of photodynamic therapy and pulsed-dye laser treatment of port-wine stain birthmarks.
MedLine Citation:
PMID:  23137063     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pulsed-dye laser (PDL)-mediated photothermolysis is the current standard treatment for port-wine stain (PWS) birthmarks. Vascular-targeted photodynamic therapy (PDT) might be an alternative for the treatment of PWS.
OBJECTIVES: To compare clinical outcomes of PDT and PDL treatment of PWS.
METHODS: Two adjacent flat areas of PWS lesions were selected from each of 15 patients (two male and 13 female; age 11-36 years) and randomly assigned to either single-session PDL or PDT. PDL was delivered using a 585-nm pulsed laser. PDT was carried out with a combination of haematoporphyrin monomethyl ether (HMME) and a low-power copper vapour laser (510.6 and 578.2 nm). Clinical outcomes were evaluated colorimetrically and visually during follow-up.
RESULTS: A total of nine red PWS lesions and six purple PWS lesions were treated. For red PWS, colorimetric assessment showed that the blanching rates of PDL and PDT at 2 months ranged from -11% to 24% and 22% to 55%, respectively. For purple PWS, blanching rates of PDL and PDT ranged from 8% to 33% and 30% to 45%, respectively. Overall, there was a significant difference between the blanching effect of single-session PDL treatment and a single-session PDT treatment.
CONCLUSIONS: This side-by-side comparison demonstrates that PDT is at least as effective as PDL and, in some cases, superior. The true value of PDT for the treatment of PWS deserves further investigation.
Authors:
K Gao; Z Huang; K-H Yuan; B Zhang; Z-Q Hu
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  168     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-25     Completed Date:  2013-11-13     Revised Date:  2013-12-29    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1040-6     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. BJD © 2012 British Association of Dermatologists.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Female
Hematoporphyrin Photoradiation / methods*
Hematoporphyrins / therapeutic use*
Humans
Laser Therapy, Low-Level / methods*
Lasers, Dye / therapeutic use*
Lasers, Gas / therapeutic use*
Male
Port-Wine Stain / drug therapy,  radiotherapy,  therapy*
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Hematoporphyrins; 0/hematoporphyrin monomethyl ether

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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