| Side effect reduction of encapsulated hydrocortisone crystals by insulin/alginate shells (†). | |
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MedLine Citation:
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PMID: 21067203 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Insulin/alginate (ALG) microcapsules for controllable release and side effect reduction of a glucocorticoid have been fabricated via the layer-by-layer (LbL) assembly technique. Insulin and ALG are deposited alternately onto hydrocortisone (HC) crystals to form a core-shell structure. This insulin/ALG microcapsule can prolong the release of HC under physical conditions and control the HC release rate by adjusting the number of insulin/ALG bilayers adsorbed onto HC crystals. The release of insulin from the capsule wall exhibits a little lag, compared with that of the HC. It is a great advantage for this system because hyperglycemia caused by HC usually arises a few hours after its administration, which could be inhibited by the delayed release of insulin from the shell of the microcapsule. This synergy effect might enable a new way of using one carrier to deliver two kinds of drugs and reduce their side effects at the same time. |
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Authors:
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Jie Zhao; Yue Cui; Anhe Wang; Jinbo Fei; Yang Yang; Junbai Li |
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Publication Detail:
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Type: Journal Article Date: 2010-11-10 |
Journal Detail:
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Title: Langmuir : the ACS journal of surfaces and colloids Volume: 27 ISSN: 1520-5827 ISO Abbreviation: Langmuir Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9882736 Medline TA: Langmuir Country: United States |
Other Details:
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Languages: eng Pagination: 1499-504 Citation Subset: IM |
Affiliation:
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Beijing National Laboratory for Molecular Sciences (BNLMS), Key Lab of Colloid and Interface Sciences, Institute of Chemistry, Chinese Academy of Sciences, No. 2, Bei Yi Jie, Zhong Guan Cun, Beijing 100190, PR China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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