| Sickness behavior as a new target for drug development. | |
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MedLine Citation:
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PMID: 1542935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sickness behavior refers to the nonspecific symptoms (anorexia, depressed activity, loss of interest in usual activities, disappearance of body-care activities) that accompany the response to infection. Increasing evidence suggests that these symptoms are part of an organized defense response to antigenic challenge and that they are mediated by the neural effects of cytokines such as interleukin 1. An understanding of the mechanisms involved in these effects should permit development of new drugs aimed at decreasing sickness or promoting recovery processes. |
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Authors:
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S Kent; R M Bluthé; K W Kelley; R Dantzer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Trends in pharmacological sciences Volume: 13 ISSN: 0165-6147 ISO Abbreviation: Trends Pharmacol. Sci. Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-04-07 Completed Date: 1992-04-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906158 Medline TA: Trends Pharmacol Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 24-8 Citation Subset: IM |
Affiliation:
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INRA-INSERM Unité 176, Bordeaux, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cytokines
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physiology* Humans Infection / drug therapy, physiopathology* Interleukin-1 / physiology |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interleukin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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