| Sicklemia with multi-organ failure syndrome and thrombotic thrombocytopenic purpura. | |
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MedLine Citation:
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PMID: 12484629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute multi-organ failure syndrome is a rare and life-threatening complication of patients with sickle cell disease. The syndrome appears to be reversed with prompt, aggressive exchange transfusion therapy. It has been attributed to widespread vascular occlusion due to micro-vascular red cell sickling. We present a case of severe multi-organ failure in a patient with sickle thalassemia and mild clinical course, who had clinical and laboratory features consistent with thrombotic thrombocytopenic purpura (TTP). The dramatic response to therapy with plasma exchange, a treatment often effective in TTP, suggests a similarity in pathophysiology of micro-vascular occlusion and multi-organ failure in sickle cell disease. |
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Authors:
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Aref Chehal; Ali Taher; Ali Shamseddine |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Hemoglobin Volume: 26 ISSN: 0363-0269 ISO Abbreviation: Hemoglobin Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-12-17 Completed Date: 2003-05-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7705865 Medline TA: Hemoglobin Country: United States |
Other Details:
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Languages: eng Pagination: 345-51 Citation Subset: IM |
Affiliation:
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Division of Hematology-Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Box 113-6044, Beirut 1107 2802, Lebanon. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia, Sickle Cell / complications*, therapy Humans Male Multiple Organ Failure / etiology*, therapy Plasma Exchange Purpura, Thrombotic Thrombocytopenic / diagnosis*, therapy Syndrome Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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