Document Detail

Sicklemia with multi-organ failure syndrome and thrombotic thrombocytopenic purpura.
MedLine Citation:
PMID:  12484629     Owner:  NLM     Status:  MEDLINE    
Acute multi-organ failure syndrome is a rare and life-threatening complication of patients with sickle cell disease. The syndrome appears to be reversed with prompt, aggressive exchange transfusion therapy. It has been attributed to widespread vascular occlusion due to micro-vascular red cell sickling. We present a case of severe multi-organ failure in a patient with sickle thalassemia and mild clinical course, who had clinical and laboratory features consistent with thrombotic thrombocytopenic purpura (TTP). The dramatic response to therapy with plasma exchange, a treatment often effective in TTP, suggests a similarity in pathophysiology of micro-vascular occlusion and multi-organ failure in sickle cell disease.
Aref Chehal; Ali Taher; Ali Shamseddine
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hemoglobin     Volume:  26     ISSN:  0363-0269     ISO Abbreviation:  Hemoglobin     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-12-17     Completed Date:  2003-05-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7705865     Medline TA:  Hemoglobin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  345-51     Citation Subset:  IM    
Division of Hematology-Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Box 113-6044, Beirut 1107 2802, Lebanon.
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MeSH Terms
Anemia, Sickle Cell / complications*,  therapy
Multiple Organ Failure / etiology*,  therapy
Plasma Exchange
Purpura, Thrombotic Thrombocytopenic / diagnosis*,  therapy
Treatment Outcome

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