Document Detail


Sickle cell nephropathy: challenging the conventional wisdom.
MedLine Citation:
PMID:  21203778     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This review explores the current model of sickle cell nephropathy and the limitations of the model. Renal abnormalities are common complications of sickle cell disease (SCD). Beginning in childhood, patients with SCD develop a urinary concentrating defect resulting in polyuria and a predisposition to nocturnal enuresis and dehydration. The current model of sickle cell nephropathy suggests that destruction of the renal medulla induces production of renal vasodilating substances that feedback to the glomerulus causing hyperfiltration. Hyperfiltration leads to glomerulosclerosis and proteinuria, with eventual reduction in kidney function. The crucial steps of vasodilating substance production and hyperfiltration in children with SCD have not been proven. Treatment of sickle cell nephropathy is aimed at the reduction of proteinuria with angiotensin converting enzyme inhibitors or angiotensin receptor blockers. Hydroxyurea and chronic transfusion therapy may also alter the progression of sickle cell nephropathy in children. Further studies are needed to identify an accurate model and effective treatments for sickle cell nephropathy.
Authors:
Amy M Becker
Related Documents :
7637558 - The effect of two synthetic phospholipids on cell proliferation and phosphatidylcholine...
196628 - Response of adrenal tumor cells to adrenocorticotropin: site of inhibition by cytochala...
9488688 - Scavenger receptor class b type i as a mediator of cellular cholesterol efflux to lipop...
12762838 - Lipids in blood-brain barrier models in vitro ii: influence of glial cells on lipid cla...
12437128 - Neuronal no synthase and its inhibitor pin are present and influenced by glucose in the...
11880278 - Satellite cell proliferation and differentiation during postnatal growth of porcine ske...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-4
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  -     ISSN:  1432-198X     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9063, USA, amy.becker@utsouthwestern.edu.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Treatment strategies for Henoch-Schönlein purpura nephritis by histological and clinical severity.
Next Document:  Blood pressure profile in renal transplant recipients and its relation to diastolic function: tissue...