| Sickle cell membranes and oxidative damage. | |
| | |
MedLine Citation:
|
PMID: 3800879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sickle erythrocytes and their membranes are susceptible to endogenous free-radical-mediated oxidative damage which correlates with the proportion of irreversibly sickled cells. The suppression of incubation-induced oxidative stress by antioxidants, free radical scavengers and an iron chelator suggest that oxidation products of membrane-bound haemoglobin contribute towards the pathology of the disease. |
| | |
Authors:
|
C Rice-Evans; S C Omorphos; E Baysal |
Related Documents
:
|
1459249 - A mechanism for nadph inhibition of catalase compound ii formation. 702049 - An approach to the development of new drugs for african trypanosomiasis. 7151009 - Further studies on free-radical pathology in the major central nervous system disorders... 11924759 - Radioprotection by a herbal preparation of hippophae rhamnoides, rh-3, against whole bo... 19647459 - Effect of aqueous environment in chemical reactivity of monolignols. a new fukui functi... 2556889 - Free radicals and their interpretations. 17971329 - Why did nature choose manganese to make oxygen? 34569 - Oxidation of the sulfhydryl forms of insulin a-chain and b-chain. 699189 - Sulfate conjugation of benzo[alpha]pyrene metabolites and derivates. |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Biochemical journal Volume: 237 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1986 Jul |
Date Detail:
|
Created Date: 1987-01-28 Completed Date: 1987-01-28 Revised Date: 2010-09-10 |
Medline Journal Info:
|
Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 265-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anemia, Sickle Cell
/
blood* Antioxidants / pharmacology Ascorbic Acid / pharmacology Deferoxamine / pharmacology Erythrocyte Membrane / drug effects, metabolism* Erythrocytes, Abnormal / drug effects, metabolism* Free Radicals Humans Iron / pharmacology Oxidation-Reduction |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Free Radicals; 50-81-7/Ascorbic Acid; 70-51-9/Deferoxamine; 7439-89-6/Iron |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phorbol ester inhibits angiotensin-induced activation of phospholipase C in adrenal glomerulosa cell...
Next Document: Disulphide reduction in lysosomes. The role of cysteine.