Document Detail


Sickle cell membranes and oxidative damage.
MedLine Citation:
PMID:  3800879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sickle erythrocytes and their membranes are susceptible to endogenous free-radical-mediated oxidative damage which correlates with the proportion of irreversibly sickled cells. The suppression of incubation-induced oxidative stress by antioxidants, free radical scavengers and an iron chelator suggest that oxidation products of membrane-bound haemoglobin contribute towards the pathology of the disease.
Authors:
C Rice-Evans; S C Omorphos; E Baysal
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  237     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1987-01-28     Completed Date:  1987-01-28     Revised Date:  2010-09-10    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  265-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anemia, Sickle Cell / blood*
Antioxidants / pharmacology
Ascorbic Acid / pharmacology
Deferoxamine / pharmacology
Erythrocyte Membrane / drug effects,  metabolism*
Erythrocytes, Abnormal / drug effects,  metabolism*
Free Radicals
Humans
Iron / pharmacology
Oxidation-Reduction
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Free Radicals; 50-81-7/Ascorbic Acid; 70-51-9/Deferoxamine; 7439-89-6/Iron
Comments/Corrections

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