Document Detail


Sickle cell disease associated with uric acid deposition disease.
MedLine Citation:
PMID:  7436565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The infrequent occurrence of gout in patients with sickle cell anaemia contrast with the high incidence of hyperuricaemia and impaired renal function. This report records the third case of synovial membrane uric acid deposition and the first case of tophaceous deposits in haemoglobin SS patients. The limitations of a diagnosis of gout on the basis of hyperuricaemia and arthritis are confirmed. Analysis of reported cases suggests the existence of 2 forms of arthritis associated with sickle cell anaemia--noninflammatory and inflammatory. Paradoxically, gout appears to be associated with the former, in which the pathophysiological changes probably prevent or diminish the acute inflammatory response.
Authors:
B M Rothschild; C W Sienknecht; S B Kaplan; J S Spindler
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  39     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1980 Aug 
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  392-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia, Sickle Cell / complications*
Foot / radiography
Gout / etiology*,  radiography
Hand / radiography
Humans
Male
Middle Aged
Grant Support
ID/Acronym/Agency:
AM-05055/AM/NIADDK NIH HHS; AM-12049/AM/NIADDK NIH HHS
Comments/Corrections

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