Document Detail

Sickle cell anemia with moyamoya disease: outcomes after EDAS procedure.
MedLine Citation:
PMID:  14580655     Owner:  NLM     Status:  MEDLINE    
Moyamoya disease is a relatively uncommon neurovascular complication of sickle cell anemia. We report a case series of six patients with sickle cell anemia who developed moyamoya disease and underwent encephaloduroarteriosynangiosis procedures. These six patients presented with either cerebrovascular accidents, transient ischemic attacks, or seizures, and subsequent magnetic resonance imaging scans were suggestive of moyamoya-like changes in the cerebral vasculature. Conventional cerebral angiography was used to confirm the diagnosis in all six patients. Four of six patients manifested a cerebrovascular accident before surgery, and two of these patients were compliant on a transfusion protocol at the time of their cerebrovascular accident. Bilateral (n = 4) or unilateral (n = 2) encephaloduroarteriosynangiosis procedures were performed without any complications. The patient who was stroke-free preoperatively had a cerebrovascular accident 2 weeks after the procedure; otherwise, all patients have remained free of neurovascular complications with an average follow-up of 33 months. Collateral anastomoses between external and internal carotid arteries were established by magnetic resonance angiography in three patients. The encephaloduroarteriosynangiosis procedure is a safe and effective treatment option in patients with sickle cell anemia who develop moyamoya disease.
Robert H Fryer; Richard C Anderson; Claudia A Chiriboga; Neil A Feldstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  29     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-10-28     Completed Date:  2004-01-09     Revised Date:  2006-05-23    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  124-30     Citation Subset:  IM    
Division of Pediatric Neurology, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
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MeSH Terms
Anemia, Sickle Cell / complications*
Cerebral Angiography
Cerebral Revascularization* / adverse effects,  methods
Magnetic Resonance Imaging
Moyamoya Disease / etiology,  surgery*

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