| Sickle cell trait and development of microvascular complications in diabetes mellitus. | |
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MedLine Citation:
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PMID: 20299376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Many African Americans (AA) have both sickle cell trait (SCT) and diabetes mellitus. The objective of this study was to determine whether individuals with diabetes mellitus and SCT have higher rates of microvascular complications relative to those without SCT. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was a retrospective study comparing albuminuria, estimated GFR (eGFR), and microvascular complications in AA with diabetes on the basis of presence of SCT. The study included 821 outpatients who underwent hemoglobin A1c (HbA1c) testing, and presence of SCT was determined using the HbA1c assay. Medical record review and telephone interviews were performed for AA participants. RESULTS: Data were obtained on 376 AA patients (110 with SCT, 245 with neither SCT nor hemoglobin C trait, and 21 with hemoglobin C trait) and 445 European Americans. The mean eGFR and urinary protein excretion were similar between the three AA subgroups. Analysis revealed that 36.3% of AA nontrait and 22.7% of AA SCT participants had retinopathy, peripheral vascular disease, or end-stage kidney disease (P = 0.01). After adjustment for diabetes duration, age, insulin use, and gender, differences in the prevalence of microvascular complications were not observed. CONCLUSIONS: SCT does not increase the risk of microvascular complications in AA with diabetes mellitus. |
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Authors:
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Anthony J Bleyer; Sri V Reddy; Leon Sujata; Gregory B Russell; Damilola Akinnifesi; Anthony J Bleyer; Donald Hire; Zak Shihabi; Mary Ann Knovich; Pirouz Daeihagh; Jorge Calles; Barry I Freedman |
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Publication Detail:
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Type: Journal Article Date: 2010-03-18 |
Journal Detail:
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Title: Clinical journal of the American Society of Nephrology : CJASN Volume: 5 ISSN: 1555-905X ISO Abbreviation: Clin J Am Soc Nephrol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-09 Completed Date: 2010-09-20 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101271570 Medline TA: Clin J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 1015-20 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. ableyer@wfubmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Academic Medical Centers Adult African Americans* / statistics & numerical data Aged Albuminuria / etiology, physiopathology Biological Markers / blood Diabetes Mellitus / blood, ethnology*, physiopathology Diabetic Nephropathies / ethnology, etiology Diabetic Retinopathy / ethnology, etiology* European Continental Ancestry Group* / statistics & numerical data Female Glomerular Filtration Rate Hemoglobin A, Glycosylated / analysis Humans Kidney Failure, Chronic / ethnology Logistic Models Male Middle Aged North Carolina Peripheral Vascular Diseases / ethnology, etiology* Retrospective Studies Risk Assessment Risk Factors Sickle Cell Trait / blood, complications*, ethnology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Hemoglobin A, Glycosylated; 0/hemoglobin A1c protein, human |
| Comments/Corrections | |
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