Document Detail

Sickle Cell Trait-Associated Deaths: A Case Series with a Review of the Literature*(,†).
MedLine Citation:
PMID:  21480898     Owner:  NLM     Status:  Publisher    
  This study presents a series of 16 carriers of hemoglobin S (HbS) who died during various circumstances. Many of the cases were associated with mild to moderate exertion. The onset and/or duration of symptoms varied from a few minutes to several hours with many displaying a prolonged lucid interval with stable vital signs. Despite seeking medical treatment, sickle cell trait-related micro-occlusive crisis was never considered in the differential diagnosis. Several cases were associated with sudden death. In those deaths which were delayed, high anion gap and uncompensated metabolic acidosis were typical and were not heat related. Also characteristic were large increases in creatine kinase, alanine aminotransferase, and aspartate aminotransferase along with myoglobinemia. Although the antemortem diagnosis of rhabdomyolysis was made, the underlying cause was never deduced by the clinicians. The sickling found at autopsy is not always a postmortem artifact, and in the right circumstances can be diagnostic.
Jon R Thogmartin; Christopher I Wilson; Noel A Palma; Susan S Ignacio; Mark J Shuman; Lisa M Flannagan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-11
Journal Detail:
Title:  Journal of forensic sciences     Volume:  -     ISSN:  1556-4029     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 American Academy of Forensic Sciences.
District Six Medical Examiner Office, 10900 Ulmerton Road, Largo, FL 33778. District Eleven Medical Examiner Office, #1 on Bob Hope Road, Miami, FL 33136. District Two Medical Examiner Office, 1899 Eider Court, Tallahassee, FL 32317.
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