Document Detail


Sickle cell microRNAs inhibit the malaria parasite.
MedLine Citation:
PMID:  22901533     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Sickle cell hemoglobin conveys resistance to malaria. In this issue of Cell Host & Microbe, LaMonte et al. (2012) demonstrate a surprising mechanism for this innate immunity. A microRNA enriched in sickle red blood cells is translocated into the parasite, incorporated covalently into P. falciparum mRNAs and inhibits parasite growth.
Authors:
Manoj T Duraisingh; Harvey F Lodish
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Cell host & microbe     Volume:  12     ISSN:  1934-6069     ISO Abbreviation:  Cell Host Microbe     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-20     Completed Date:  2013-01-16     Revised Date:  2013-07-31    
Medline Journal Info:
Nlm Unique ID:  101302316     Medline TA:  Cell Host Microbe     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-8     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Harvard School of Public Health, Boston, MA 02115, USA. mduraisi@hsph.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 DK068348/DK/NIDDK NIH HHS
Comments/Corrections
Comment On:
Cell Host Microbe. 2012 Aug 16;12(2):187-99   [PMID:  22901539 ]

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