Document Detail

Sickle cell disease and transcranial Doppler imaging: inter-hemispheric differences in blood flow Doppler parameters.
MedLine Citation:
PMID:  21088242     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: to establish reference values of interhemispheric differences and ratios of blood flow Doppler parameters in the terminal internal carotid artery, middle cerebral artery, and anterior cerebral artery in children with sickle cell anemia.
METHODS: fifty-seven out of 74 recruited children (mean age, 7.8 ± 3.4 years; range limits, 3-14 years), who were free of neurological deficits and intracranial narrowing detectable by MRA and had flow velocities <170 cm/s by conventional transcranial Doppler ultrasound, underwent transcranial color-coded duplex ultrasonography. Reference limits of flow parameters corrected and uncorrected for the angle of insonation were estimated using tolerance intervals, with P=0.90 for all possible data values from 95% of a population.
RESULTS: reference limits for left-to-right differences in cm/s in the mean angle-corrected and uncorrected flow velocities were -56 to 53 and -72 to 75 for middle cerebral artery, -49 to 57 and -81 to 91 for anterior cerebral artery, and -55 to 64 and -73 to 78 for terminal internal carotid artery, respectively. Respective reference limits for left-to-right velocity ratios were 0.31 to 1.84 and 0.38 to 1.75 for middle cerebral artery, 0.48 to 2.99 and 0.46 to 2.89 for anterior cerebral artery, and 0.61 to 2.56 and 0.56 to 2.23 for terminal internal carotid artery.
CONCLUSIONS: the study provides reference limits of interhemispheric differences and ratios of blood flow Doppler parameters that may be helpful in identification of intracranial arterial narrowing in children with sickle cell disease undergoing ultrasound screening for stroke prevention.
Jaroslaw Krejza; Rong Chen; Grzegorz Romanowicz; Janet L Kwiatkowski; Rebecca Ichord; Michal Arkuszewski; Robert Zimmerman; Kwaku Ohene-Frempong; Lisa Desiderio; Elias R Melhem
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural     Date:  2010-11-18
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  42     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-28     Completed Date:  2011-01-28     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-6     Citation Subset:  IM    
Department of Radiology, Division of Neuroradiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
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MeSH Terms
Anemia, Sickle Cell / complications,  physiopathology*,  ultrasonography*
Anterior Cerebral Artery* / physiopathology,  ultrasonography
Blood Flow Velocity
Carotid Artery, Internal* / physiopathology,  ultrasonography
Child, Preschool
Cross-Sectional Studies
Middle Cerebral Artery* / physiopathology,  ultrasonography
Prospective Studies
Stroke / etiology,  physiopathology,  prevention & control,  ultrasonography
Ultrasonography, Doppler, Transcranial*
Grant Support
5-R01 NS-046717/NS/NINDS NIH HHS; R01 NS046717-01A1/NS/NINDS NIH HHS

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