Document Detail

Sickle Cell Disease Related Mortality in the United States (1999-2009).
MedLine Citation:
PMID:  23637037     Owner:  NLM     Status:  Publisher    
BACKGROUND: Little is known about the national outcome of children and adults with sickle cell disease (SCD) given contemporary care. PROCEDURE: We investigated the number of deaths, standardized crude and age-adjusted mortality rates, and causes of death among individuals with SCD across the United States during 1999-2009 according to death certificates by using a publicly available website ( Data were compared to mortality during 1979-1998. RESULTS: When compared to 1979-1998, mortality significantly decreased by 61% in infants <1 year of age, by 67% in children aged 1-4 years, and by 22-35% in children aged 5-19 years. After 19 years of age, mortality rates increased from 0.6 in the 15-19 year group to 1.4/100,000 in the 20-24 year group, corresponding to the transition period from pediatric to adult medical care, and this increase was similar during 1979-1998. Although the age groups with the highest mortality were 35-44 years for males and 45-54 years for females, there was a tendency for longer survival because there were more deaths among those individuals 55-74 years of age compared to previous years. For all individuals, the causes of deaths were cardiac disease (31.6%), respiratory (28.1%), renal (16.4%), infectious (14.4%), neurologic (11.9%), and gastrointestinal and hepatobiliary (9.2%) in nature. Cancer was the cause of death in <1%. CONCLUSION: Mortality during childhood has decreased significantly. However, the transition period from pediatric to adult care is critical. Risk-reduction, monitoring, and early treatment intervention of cardiovascular disease in adults is warranted. Pediatr Blood Cancer 2013;9999:XX-XX. © 2013 Wiley Periodicals, Inc.
Dima Hamideh; Ofelia Alvarez
Related Documents :
7496967 - T-cell responses to infected autologous monocytes in patients with cutaneous and mucocu...
24943417 - A new colombian species of cryptocellus (arachnida, ricinulei), with notes on the taxon...
24968577 - Comparative study of effect of anuloma-viloma (pranayam) and yogic asanas in premenstru...
24159147 - Effects of sport involvement in assets, attitudes and enjoyment in youth soccer players.
23973707 - Reproductive effort and success of wild female mallards: does male quality matter?
24267487 - Processing of non-canonical word-order: a case-series on lesion-induced reorganized lan...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-23
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  -     ISSN:  1545-5017     ISO Abbreviation:  Pediatr Blood Cancer     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-5-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
Division of Pediatric Hematology, University of Miami Miller School of Medicine, Miami, Florida.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The catheter-over-needle assembly facilitates delivery of a second local anesthetic bolus to prolong...
Next Document:  Increased serum microRNA-155 level associated with non-responsiveness to hepatitis B vaccine.